Impact of particle size and polydispersity index on the clinical applications of lipidic nanocarrier systems

M Danaei, M Dehghankhold, S Ataei… - Pharmaceutics, 2018 - mdpi.com
Lipid-based drug delivery systems, or lipidic carriers, are being extensively employed to
enhance the bioavailability of poorly-soluble drugs. They have the ability to incorporate both …

Update and new insights on future cancer drug candidates from plant-based alkaloids

M Tilaoui, H Ait Mouse, A Zyad - Frontiers in Pharmacology, 2021 - frontiersin.org
Cancer is a complex multifactorial disease that results from alterations in many physiological
and biochemical functions. Over the last few decades, it has become clear that cancer cells …

Cancer‐cell‐biomimetic nanoparticles for targeted therapy of multiple myeloma based on bone marrow homing

Y Qu, B Chu, X Wei, Y Chen, Y Yang, D Hu… - Advanced …, 2022 - Wiley Online Library
Multiple myeloma (MM) is the second most common hematological malignancy. It is
characterized by abnormal transformation and uncontrolled clonal proliferation of malignant …

Application of stem cells in regeneration medicine

Y Jin, S Li, Q Yu, T Chen, D Liu - MedComm, 2023 - Wiley Online Library
Regeneration is a complex process affected by many elements independent or combined,
including inflammation, proliferation, and tissue remodeling. Stem cells is a class of primitive …

[HTML][HTML] Homoharringtonine, an approved anti-leukemia drug, suppresses triple negative breast cancer growth through a rapid reduction of anti-apoptotic protein …

M Yakhni, A Briat, A El Guerrab, L Furtado… - American journal of …, 2019 - ncbi.nlm.nih.gov
Triple negative breast cancers (TNBC) without BRCA1/2 gene mutation or BRCAness are
nowadays the breast malignancies most difficult to treat. Improvement of their treatment, for …

Nanoliposomes as drug delivery systems: Safety concerns

YA Tereshkina, TI Torkhovskaya… - Journal of Drug …, 2022 - Taylor & Francis
The review highlights the safety issues of drug delivery systems based on liposomes. Due to
their small sizes (about 80–120 nm, sometimes even smaller), phospholipid nanoparticles …

Tumor microenvironment: a prospective target of natural alkaloids for cancer treatment

Y Luo, S Yin, J Lu, S Zhou, Y Shao, X Bao… - Cancer Cell …, 2021 - Springer
Malignant tumor has become one of the major diseases that seriously endangers human
health. Numerous studies have demonstrated that tumor microenvironment (TME) is closely …

Specifically eliminating tumor-associated macrophages with an extra-and intracellular stepwise-responsive nanocarrier for inhibiting metastasis

N Guo, Y Zhou, T Wang, M Lin, J Chen… - … applied materials & …, 2020 - ACS Publications
Metastasis is the primary cause of death for most cancer patients, in which tumor-associated
macrophages (TAMs) are involved through several mechanisms. While hitherto there is still …

F7 and topotecan co-loaded thermosensitive liposome as a nano-drug delivery system for tumor hyperthermia

C Du, S Li, Y Li, H Galons, N Guo, Y Teng, Y Zhang… - Drug …, 2020 - Taylor & Francis
In order to enhance the targeting efficiency and reduce anti-tumor drug's side effects,
topotecan (TPT) and F7 were co-loaded in thermosensitive liposomes (F7-TPT-TSL), which …

Targeted Delivery Strategies for Multiple Myeloma and Their Adverse Drug Reactions

S Li, H Wang, S Xiong, J Liu, S Sun - Pharmaceuticals, 2024 - mdpi.com
Currently, multiple myeloma (MM) is a prevalent hematopoietic system malignancy, known
for its insidious onset and unfavorable prognosis. Recently developed chemotherapy drugs …