[HTML][HTML] Anticoagulant and signaling functions of antithrombin

AR Rezaie, H Giri - Journal of Thrombosis and Haemostasis, 2020 - Elsevier
Antithrombin (AT) is a major plasma glycoprotein of the serpin superfamily that regulates the
proteolytic activity of the procoagulant proteases of both intrinsic and extrinsic pathways …

Astrocytes and the TGF-β1 pathway in the healthy and diseased brain: a double-edged sword

LP Diniz, I Matias, M Siqueira, J Stipursky… - Molecular …, 2019 - Springer
Transforming growth factor betas (TGF-βs) are known as multifunctional growth factors that
participate in the regulation of key events of development, disease, and tissue repair. In the …

The transcription factor PAX8 promotes angiogenesis in ovarian cancer through interaction with SOX17

D Chaves-Moreira, MA Mitchell, C Arruza, P Rawat… - Science …, 2022 - science.org
PAX8 is a master transcription factor that is essential during embryogenesis and promotes
neoplastic growth. It is expressed by the secretory cells lining the female reproductive tract …

[HTML][HTML] Bio-instructive hydrogel expands the paracrine potency of mesenchymal stem cells

NM Drzeniek, A Mazzocchi, S Schlickeiser… - …, 2021 - iopscience.iop.org
The therapeutic efficacy of clinically applied mesenchymal stromal cells (MSCs) is limited
due to their injection into harsh in vivo environments, resulting in the significant loss of their …

Diverse homeostatic and immunomodulatory roles of immune cells in the developing mouse lung at single cell resolution

R Domingo-Gonzalez, F Zanini, X Che, M Liu… - Elife, 2020 - elifesciences.org
At birth, the lungs rapidly transition from a pathogen-free, hypoxic environment to a
pathogen-rich, rhythmically distended air-liquid interface. Although many studies have …

Primary head and neck tumour-derived fibroblasts promote lymphangiogenesis in a lymphatic organotypic co-culture model

KM Lugo-Cintrón, JM Ayuso, M Humayun, MM Gong… - …, 2021 - thelancet.com
Background In head and neck cancer, intratumour lymphatic density and tumour
lymphangiogenesis have been correlated with lymphatic metastasis, making …

Role of extracellular vesicles from adipose tissue-and bone marrow-mesenchymal stromal cells in endothelial proliferation and chondrogenesis

C Gorgun, MEF Palamà, D Reverberi… - Stem Cells …, 2021 - academic.oup.com
The secretome of mesenchymal stromal cells (MSCs) derived from different tissue sources is
considered an innovative therapeutic tool for regenerative medicine. Although adipose …

Exosomes derived from induced vascular progenitor cells promote angiogenesis in vitro and in an in vivo rat hindlimb ischemia model

TK Johnson, L Zhao, D Zhu, Y Wang… - American Journal …, 2019 - journals.physiology.org
Induced vascular progenitor cells (iVPCs) were created as an ideal cell type for regenerative
medicine and have been reported to positively promote collateral blood flow and improve …

PAI-1 exacerbates white adipose tissue dysfunction and metabolic dysregulation in high fat diet-induced obesity

L Wang, L Chen, Z Liu, Y Liu, M Luo, N Chen… - Frontiers in …, 2018 - frontiersin.org
Background: Plasminogen activator inhibitor (PAI)-1 levels and activity are known to
increase during metabolic syndrome and obesity. In addition, previous studies have …

Adipose tissue development relies on coordinated extracellular matrix remodeling, angiogenesis, and adipogenesis

EK Johnston, RD Abbott - Biomedicines, 2022 - mdpi.com
Despite developing prenatally, the adipose tissue is unique in its ability to undergo drastic
growth even after reaching its mature size. This development and subsequent maintenance …