Protein tyrosine phosphorylation is a key regulatory process in virtually all aspects of cellular
functions. Dysregulation of protein tyrosine phosphorylation is a major cause of human …

DUSPs (dual-specificity phosphatases) are a heterogeneous group of protein phosphatases
that can dephosphorylate both phosphotyrosine and phosphoserine/phosphothreonine …

Protein tyrosine phosphatase 1B (PTP1B) is an effective target for the treatment of both type
2 diabetes and obesity; however, targeting PTP1B for drug discovery is challenging because …

Overexpression of phosphatase of regenerating liver (PRL)-3 is associated with the
progression of diverse human cancers. We show that the overexpression of PRL-3 protein is …

PRL-3 is a metastasis-associated phosphatase. We and others have shown that its
overexpression increases cell motility and invasiveness. These phenotypic changes are …

Metastasis is responsible for 90% of cancer patient deaths. More information is needed
about the molecular basis for its potential detection and treatment. The activated AKT kinase …

Phosphatase found in regenerating liver (PRL)-1, PRL-2, and PRL-3 [also known as
PTP4A1, PTP4A2, and PTP4A3, respectively] constitute a unique family of putative protein …

An appropriate level of protein phosphorylation on tyrosine is essential for cells to react to
extracellular stimuli and maintain cellular homeostasis. Faulty operation of signal pathways …

Protein tyrosine phosphatases (PTPs) are a diverse family of enzymes encoded by 107
genes in the human genome. Together with protein tyrosine kinases (PTKs), PTPs regulate …

Phosphatase of regenerating liver 3 (PRL3) is overexpressed in a variety of tumors, and
high levels of PRL3 expression are associated with tumorigenesis and metastasis …