Downstream targets of Rho In the past year, a number of proteins that bind to Rho in a GTP-
dependent manner have been identified by yeast two-hybrid analysis or by affinity …

Post-translational modification of proteins is a widespread mechanism used by both
prokaryotic and eukaryotic cells to modify the activity of key factors that plays fundamental …

Aberrant signaling through G-protein coupled receptors promotes metastasis, the major
cause of breast cancer death. We identified regulator of G-protein signaling 4 (RGS4) as a …

Three theories of regeneration dominate neuroscience today, all purporting to explain why
the adult central nervous system (CNS) cannot regenerate. One theory proposes that Nogo …

It has been previously reported that the three‐dimensional structures of the NAD‐binding
and catalytic site of bacterial toxins with ADP‐ribosylating activity are superimposable, and …

Clostridia is one of the largest bacterial genera with an enormous potential for biotechnical
and medical applications. Despite growing scientific, medical, and industrial interest …

Clostridium botulinum C3 exoenzyme inactivates the small GTP-binding protein family Rho
by ADP-ribosylating asparagine 41, which depolymerizes the actin cytoskeleton. C3 thus …

Tight junctions (TJs) and adherens junctions (AJs) are dynamic structures linked to the actin
cytoskeleton, which control the paracellular permeability of epithelial and endothelial …

The family of C3-like exoenzymes comprises seven bacterial ADP-ribosyltransferases of
different origin. The common hallmark of these exoenzymes is the selective N-ADP …

C3-like exoenzymes comprise a family of seven bacterial ADP-ribosyltransferases, which
selectively modify RhoA, B, and C at asparagine-41. Crystal structures of C3 exoenzymes …