Bioinformatics methods for mass spectrometry-based proteomics data analysis

C Chen, J Hou, JJ Tanner, J Cheng - International journal of molecular …, 2020 - mdpi.com
Recent advances in mass spectrometry (MS)-based proteomics have enabled tremendous
progress in the understanding of cellular mechanisms, disease progression, and the …

Unsupervised machine learning for exploratory data analysis in imaging mass spectrometry

N Verbeeck, RM Caprioli… - Mass spectrometry …, 2020 - Wiley Online Library
Imaging mass spectrometry (IMS) is a rapidly advancing molecular imaging modality that
can map the spatial distribution of molecules with high chemical specificity. IMS does not …

SIMS imaging in neurobiology and cell biology

P Agüi-Gonzalez, S Jähne, NTN Phan - Journal of Analytical Atomic …, 2019 - pubs.rsc.org
Secondary ion mass spectrometry (SIMS) has been increasingly recognized as a powerful
technique for visualizing molecular architectures in the fields of neurobiology and cell …

Novel trimodal MALDI imaging mass spectrometry (IMS3) at 10 μm reveals spatial lipid and peptide correlates implicated in Aβ plaque pathology in Alzheimer's …

I Kaya, D Brinet, W Michno, M Başkurt… - ACS chemical …, 2017 - ACS Publications
Multimodal chemical imaging using matrix-assisted laser desorption/ionization mass
spectrometry (MALDI-MS) can provide comprehensive molecular information in situ within …

On-tissue derivatization via electrospray deposition for matrix-assisted laser desorption/ionization mass spectrometry imaging of endogenous fatty acids in rat brain …

Q Wu, TJ Comi, B Li, SS Rubakhin… - Analytical …, 2016 - ACS Publications
Matrix-assisted laser desorption/ionization (MALDI) mass spectrometry imaging (MSI) is
used for the multiplex detection and characterization of diverse analytes over a wide mass …

Following spatial Aβ aggregation dynamics in evolving Alzheimer's disease pathology by imaging stable isotope labeling kinetics

W Michno, KM Stringer, T Enzlein, MK Passarelli… - Science …, 2021 - science.org
β-Amyloid (Aβ) plaque formation is the major pathological hallmark of Alzheimer's disease
(AD) and constitutes a potentially critical, early inducer driving AD pathogenesis as it …

Mass spectrometry imaging of biomarker lipids for phagocytosis and signalling during focal cerebral ischaemia

MMB Nielsen, KL Lambertsen, BH Clausen, M Meyer… - Scientific reports, 2016 - nature.com
Focal cerebral ischaemia has an initial phase of inflammation and tissue injury followed by a
later phase of resolution and repair. Mass spectrometry imaging (desorption electrospray …

Structural amyloid plaque polymorphism is associated with distinct lipid accumulations revealed by trapped ion mobility mass spectrometry imaging

W Michno, PM Wehrli, S Koutarapu… - Journal of …, 2022 - Wiley Online Library
Understanding of Alzheimer's disease (AD) pathophysiology requires molecular assessment
of how key pathological factors, specifically amyloid β (Aβ) plaques, influence the …

A primer on concepts and applications of proteomics in neuroscience

F Hosp, M Mann - Neuron, 2017 - cell.com
The enormous complexity of the central nervous system has impeded its systemic
exploration for decades but powerful" omic" technologies are now pushing forward the …

Biological tissue sample preparation for time-of-flight secondary ion mass spectrometry (ToF–SIMS) imaging

S Yoon, TG Lee - Nano Convergence, 2018 - Springer
Time-of-flight secondary ion mass spectrometry (ToF–SIMS) imaging is an analytical
technique rapidly expanding in use in biological studies. This technique is based on high …