[HTML][HTML] Innovative approaches for cancer treatment: Current perspectives and new challenges

C Pucci, C Martinelli, G Ciofani - ecancermedicalscience, 2019 - ncbi.nlm.nih.gov
Every year, cancer is responsible for millions of deaths worldwide and, even though much
progress has been achieved in medicine, there are still many issues that must be addressed …

Aptamers chemistry: Chemical modifications and conjugation strategies

F Odeh, H Nsairat, W Alshaer, MA Ismail, E Esawi… - Molecules, 2019 - mdpi.com
Soon after they were first described in 1990, aptamers were largely recognized as a new
class of biological ligands that can rival antibodies in various analytical, diagnostic, and …

Synthetic nanoparticles for vaccines and immunotherapy

DJ Irvine, MC Hanson, K Rakhra, T Tokatlian - Chemical reviews, 2015 - ACS Publications
The immune system plays a critical role in our health. No other component of human
physiology plays a decisive role in as diverse an array of maladies, from deadly diseases …

Nanomaterials enhanced surface plasmon resonance for biological and chemical sensing applications

S Zeng, D Baillargeat, HP Ho, KT Yong - Chemical Society Reviews, 2014 - pubs.rsc.org
The main challenge for all electrical, mechanical and optical sensors is to detect low
molecular weight (less than 400 Da) chemical and biological analytes under extremely …

Cancer active targeting by nanoparticles: a comprehensive review of literature

R Bazak, M Houri, S El Achy, S Kamel… - Journal of cancer research …, 2015 - Springer
Purpose Cancer is one of the leading causes of death, and thus, the scientific community
has but great efforts to improve cancer management. Among the major challenges in cancer …

The role of inflammasomes in human diseases and their potential as therapeutic targets

J Yao, K Sterling, Z Wang, Y Zhang… - Signal Transduction and …, 2024 - nature.com
Inflammasomes are large protein complexes that play a major role in sensing inflammatory
signals and triggering the innate immune response. Each inflammasome complex has three …

Aptamer-based biosensors for biomedical diagnostics

W Zhou, PJJ Huang, J Ding, J Liu - Analyst, 2014 - pubs.rsc.org
Aptamers are single-stranded nucleic acids that selectively bind to target molecules. Most
aptamers are obtained through a combinatorial biology technique called SELEX. Since …

Transparent reporting of a multivariable prediction model for individual prognosis or diagnosis (TRIPOD) the TRIPOD statement

GS Collins, JB Reitsma, DG Altman, KGM Moons - Circulation, 2015 - Am Heart Assoc
Background—Prediction models are developed to aid health care providers in estimating
the probability or risk that a specific disease or condition is present (diagnostic models) or …

[HTML][HTML] Biomedical applications of aptamer-modified chitosan nanomaterials: An updated review

S Fathi-Karkan, S Mirinejad, F Ulucan-Karnak… - International Journal of …, 2023 - Elsevier
Among polysaccharides of environmental and economic interest, chitosan (CS) is receiving
much attention, particularly in the food and biotechnology industries to encapsulate active …

G-quadruplex-forming aptamers—characteristics, applications, and perspectives

C Roxo, W Kotkowiak, A Pasternak - Molecules, 2019 - mdpi.com
G-quadruplexes constitute a unique class of nucleic acid structures formed by G-rich
oligonucleotides of DNA-or RNA-type. Depending on their chemical nature, loops length …