[HTML][HTML] Implication of Rac1 GTPase in molecular and cellular mitochondrial functions
C Bailly, C Degand, W Laine, V Sauzeau, J Kluza - Life Sciences, 2024 - Elsevier
Rac1 is a member of the Rho GTPase family which plays major roles in cell mobility, polarity
and migration, as a fundamental regulator of actin cytoskeleton. Signal transduction by Rac1 …
and migration, as a fundamental regulator of actin cytoskeleton. Signal transduction by Rac1 …
[HTML][HTML] Mitochondrial adaptation decreases drug sensitivity of persistent triple negative breast cancer cells surviving combinatory and sequential chemotherapy
M Winter, AN Eldjoudi, C Guette, H Hondermarck… - Neoplasia, 2023 - Elsevier
Triple negative breast cancer (TNBC) is an aggressive malignancy for which chemotherapy
remains the standard treatment. However, between 3 and 5 years after chemotherapy, about …
remains the standard treatment. However, between 3 and 5 years after chemotherapy, about …
Enhanced Expression of Glycolytic Enzymes and Succinate Dehydrogenase Complex Flavoprotein Subunit A by Mesothelin Promotes Glycolysis and Mitochondrial …
Y Jang, JS Koh, JH Park, S Choi, PTT Duong… - International Journal of …, 2024 - mdpi.com
Acute myeloid leukemia (AML) is an aggressive malignancy characterized by rapid growth
and uncontrolled proliferation of undifferentiated myeloid cells. Metabolic reprogramming is …
and uncontrolled proliferation of undifferentiated myeloid cells. Metabolic reprogramming is …
[PDF][PDF] Les différentes méthodes de mesure du métabolisme énergétique mitochondrial des Leucémies Aiguës Myéloïdes pour établir un biomarqueur de la réponse …
MD Claire - pepite-depot.univ-lille.fr
Ces dernières années, la prise en charge des cancers a évolué et ce, notamment grâce aux
avancées de la biologie moléculaire. Dans les années 2000, il y a eu un changement de …
avancées de la biologie moléculaire. Dans les années 2000, il y a eu un changement de …
[HTML][HTML] Key role of glutamine metabolism in persistence of leukemic cells upon exposition to FLT3 tyrosine kinase inhibitors
R Khamari, C Degand, Q Fovez, A Trinh… - Experimental …, 2024 - Elsevier
Highlights•AML-surviving iFLT3 relies on mitochondrial metabolism, mainly glutamine
oxidation.•iFLT3 and asparaginase synergize, targeting resistant AML cells.•iFLT3 and …
oxidation.•iFLT3 and asparaginase synergize, targeting resistant AML cells.•iFLT3 and …