The tumor microenvironment (TME), which includes both cellular and non-cellular elements,
is now recognized as one of the major regulators of the development of primary tumors, the …

Ischemic stroke is a leading cause of disability and mortality. Despite extensive efforts in
stroke research, the only pharmacological treatment currently available is arterial …

The innate immune compartment of the human central nervous system (CNS) is highly
diverse and includes several immune-cell populations such as macrophages that are …

The surface of the central nervous system (CNS) is protected by the meninges, which
contain a dense network of meningeal macrophages (MMs). Here, we examined the role of …

Sensory neurons in the dorsal root ganglion (DRG) and trigeminal ganglion (TG) are
specialized to detect and transduce diverse environmental stimuli to the central nervous …

The central nervous system (CNS) tightly regulates access of circulating immune cells.
Immunosurveillance is therefore managed in the meninges at the borders of the CNS. Here …

Solid tumors have a dynamic ecosystem in which malignant and non-malignant (endothelial,
stromal, and immune) cell types constantly interact. Importantly, the abundance, localization …

Meningiomas are the most common primary intracranial tumors. Although most symptomatic
cases can be managed by surgery and/or radiotherapy, a relevant number of patients …

Recent studies have highlighted spatially resolved multi-omics technologies, including
spatial genomics, transcriptomics, proteomics, and metabolomics, as powerful tools to …

High‐grade meningioma has an unsatisfactory outcome despite surgery and postoperative
radiotherapy; however, the factors driving its malignancy and recurrence remain largely …