George Weber was among the first to recognize that extensive metabolic changes must
underlie the unbridled proliferation of cancer cells. 1 His molecular correlation hypothesis …

Regulatory CBS (cystathionine β-synthase) domains exist as two or four tandem copies in
thousands of cytosolic and membrane-associated proteins from all kingdoms of life …

Soluble inorganic pyrophosphatases (PPases) catalyse an essential reaction, the hydrolysis
of pyrophosphate to inorganic phosphate. In addition, an evolutionarily ancient family of …

In its early history, life appeared to depend on pyrophosphate rather than ATP as the source
of energy. Ancient membrane pyrophosphatases that couple pyrophosphate hydrolysis to …

Cyclic di‐AMP is an essential signalling molecule in Gram‐positive bacteria. This second
messenger regulates the osmotic pressure of the cell by interacting directly with the …

Pyrophosphatases (PPases) are enzymes that catalyze the hydrolysis of pyrophosphate
(PPi), a byproduct of the synthesis and degradation of diverse biomolecules. The …

IMP dehydrogenase (IMPDH) catalyzes the pivotal step in guanine nucleotide biosynthesis.
Here we show that both IMPDH type 1 (IMPDH1) and IMPDH type 2 are associated with …

Inorganic pyrophosphatases (PP ases) convert pyrophosphate (PPi) to phosphate and are
present in all cell types. Soluble PP ases belong to three nonhomologous families, of which …

The thermophilic methanogen Methanosaeta thermophila uses acetate as sole substrate for
methanogenesis. It was proposed that the acetate activation reaction that is needed to feed …

Inosine monophosphate dehydrogenase (IMPDH) catalyzes the rate-limiting step in the de
novo biosynthesis of guanine nucleotides. In recent years it has become the target of …