New hypotheses for the health-protective mechanisms of whole-grain cereals: what is beyond fibre?

A Fardet - Nutrition research reviews, 2010 - cambridge.org
Epidemiological studies have clearly shown that whole-grain cereals can protect against
obesity, diabetes, CVD and cancers. The specific effects of food structure (increased satiety …

Biotin

J Zempleni, SSK Wijeratne, YI Hassan - Biofactors, 2009 - Wiley Online Library
Biotin is a water‐soluble vitamin and serves as a coenzyme for five carboxylases in humans.
Biotin is also covalently attached to distinct lysine residues in histones, affecting chromatin …

[图书][B] Handbook of vitamins

J Zempleni, JW Suttie, JF Gregory III, PJ Stover - 2013 - books.google.com
Within the last few years, knowledge about vitamins has increased dramatically. This new
edition of a bestseller presents comprehensive summaries that analyze the chemical …

Probiotic Bifidobacterium longum alters gut luminal metabolism through modification of the gut microbial community

H Sugahara, T Odamaki, S Fukuda, T Kato, J Xiao… - Scientific reports, 2015 - nature.com
Probiotics are well known as health-promoting agents that modulate intestinal microbiota.
However, the molecular mechanisms underlying this effect remain unclear. Using …

Biotin biochemistry and human requirements

J Zempleni, DM Mock - The Journal of nutritional biochemistry, 1999 - Elsevier
Human biotin turnover and requirements can be estimated on the basis of (1) concentrations
of biotin and metabolites in body fluids,(2) activities of biotin-dependent carboxylases, and …

Biotin deficiency enhances the inflammatory response of human dendritic cells

S Agrawal, A Agrawal, HM Said - American Journal of …, 2016 - journals.physiology.org
The water-soluble biotin (vitamin B7) is indispensable for normal human health. The vitamin
acts as a cofactor for five carboxylases that are critical for fatty acid, glucose, and amino acid …

Regulation of gene expression by biotin☆

R Rodriguez-Melendez, J Zempleni - The Journal of nutritional …, 2003 - Elsevier
In mammals, biotin serves as coenzyme for four carboxylases, which play essential roles in
the metabolism of glucose, amino acids, and fatty acids. Biotin deficiency causes decreased …

[HTML][HTML] Biotin

J Zempleni, T Kuroishi - Advances in Nutrition, 2012 - Elsevier
In mammals, biotin serves as a covalently bound coenzyme for 5 carboxylases: acetyl-CoA
carboxylases 1 and 2, propionyl-CoA carboxylase (PCC), 5 3-methylcrotonyl-CoA …

Pharmacokinetics and pharmacodynamics of MD1003 (high-dose biotin) in the treatment of progressive multiple sclerosis

L Peyro Saint Paul, D Debruyne… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Multiple sclerosis (MS) is a chronic, potentially highly disabling neurological
disorder. No disease-modifying treatments are approved in the progressive and not active …

Transgenic avidin maize is resistant to storage insect pests

KJ Kramer, TD Morgan, JE Throne, FE Dowell… - Nature …, 2000 - nature.com
Avidin is a glycoprotein found in chicken egg white, that sequesters the vitamin biotin. Here
we show that when present in maize at levels of≥ 100 ppm, avidin is toxic to and prevents …