Biotin is a water‐soluble vitamin and serves as a coenzyme for five carboxylases in humans. Biotin is also covalently attached to distinct lysine residues in histones, affecting chromatin …
Within the last few years, knowledge about vitamins has increased dramatically. This new edition of a bestseller presents comprehensive summaries that analyze the chemical …
H Sugahara, T Odamaki, S Fukuda, T Kato, J Xiao… - Scientific reports, 2015 - nature.com
Probiotics are well known as health-promoting agents that modulate intestinal microbiota. However, the molecular mechanisms underlying this effect remain unclear. Using …
J Zempleni, DM Mock - The Journal of nutritional biochemistry, 1999 - Elsevier
Human biotin turnover and requirements can be estimated on the basis of (1) concentrations of biotin and metabolites in body fluids,(2) activities of biotin-dependent carboxylases, and …
The water-soluble biotin (vitamin B7) is indispensable for normal human health. The vitamin acts as a cofactor for five carboxylases that are critical for fatty acid, glucose, and amino acid …
R Rodriguez-Melendez, J Zempleni - The Journal of nutritional …, 2003 - Elsevier
In mammals, biotin serves as coenzyme for four carboxylases, which play essential roles in the metabolism of glucose, amino acids, and fatty acids. Biotin deficiency causes decreased …
J Zempleni, T Kuroishi - Advances in Nutrition, 2012 - Elsevier
In mammals, biotin serves as a covalently bound coenzyme for 5 carboxylases: acetyl-CoA carboxylases 1 and 2, propionyl-CoA carboxylase (PCC), 5 3-methylcrotonyl-CoA …
L Peyro Saint Paul, D Debruyne… - Expert opinion on …, 2016 - Taylor & Francis
Introduction: Multiple sclerosis (MS) is a chronic, potentially highly disabling neurological disorder. No disease-modifying treatments are approved in the progressive and not active …
KJ Kramer, TD Morgan, JE Throne, FE Dowell… - Nature …, 2000 - nature.com
Avidin is a glycoprotein found in chicken egg white, that sequesters the vitamin biotin. Here we show that when present in maize at levels of≥ 100 ppm, avidin is toxic to and prevents …