Thiazoles and thiazolidinones as COX/LOX inhibitors

K Liaras, M Fesatidou, A Geronikaki - Molecules, 2018 - mdpi.com
Inflammation is a natural process that is connected to various conditions and disorders such
as arthritis, psoriasis, cancer, infections, asthma, etc. Based on the fact that cyclooxygenase …

[HTML][HTML] A review on progress of thiazole derivatives as potential anti-inflammatory agents

KH Narasimhamurthy, TR Swaroop… - European Journal of …, 2024 - Elsevier
Inflammation is a body response against infection that activates other biological components
that include various cytokines, chemokines and other biological compounds that trigger …

New thiazole carboxamide derivatives as COX inhibitors: design, synthesis, anticancer screening, in silico molecular docking, and ADME profile studies

M Hawash, N Jaradat, R Sabobeh, M Abualhasan… - ACS …, 2023 - ACS Publications
The goal of this work was to create and test a new series of thiazole carboxamide derivatives
for their cyclooxygenase (COX) suppressor and anticancer effects. The compounds were …

Design, synthesis, molecular docking studies and biological evaluation of thiazole carboxamide derivatives as COX inhibitors

M Hawash, N Jaradat, M Abualhasan, MK Şüküroğlu… - BMC chemistry, 2023 - Springer
Background Nonsteroidal anti-inflammatory drugs (NSAIDs) have been the most commonly
used class of medications worldwide for the last three decades. Objectives This study aimed …

DFT, molecular docking, and ADMET studies for the adsorption behavior and anti-inflammatory activity of thiazole by B12N12 and OH-B12N12 nanoclusters

F Pan, AT Jalil, F Alsaikhan, M Adil, AJ Kadhim… - Diamond and Related …, 2023 - Elsevier
To assess the interaction of thiazole (TZL) with the pure and hydroxyl-functionalized boron
nitride (OH-B 12 N 12) nanoclusters, we used density functional theory (DFT) and molecular …

“Azole” as privileged heterocycle for targeting the inducible cyclooxygenase enzyme

P Prasher, M Sharma - Drug Development Research, 2021 - Wiley Online Library
An over‐expression of COX‐2 isoenzyme belonging to the Cyclooxygenase Enzyme Family
triggers the overproduction of pro‐inflammatory prostaglandins that instigate the …

Fluorinated benzofuran and dihydrobenzofuran as anti-inflammatory and potential anticancer agents

AJ Ayoub, GA El-Achkar, SE Ghayad, L Hariss… - International Journal of …, 2023 - mdpi.com
Benzofuran and 2, 3-dihydrobenzofuran scaffolds are heterocycles of high value in
medicinal chemistry and drug synthesis. Targeting inflammation in cancer associated with …

[PDF][PDF] Thiazoles: A retrospective study on synthesis, structure-activity relationship and therapeutic significance

S Sharma, M Devgun, R Narang, S Lal… - Indian J. Pharm. Educ …, 2022 - academia.edu
ABSTRACT Thiazole or 1, 3-thiazole is a distinct heterocyclic compound which incorporates
sulphur and nitrogen atoms. It is a vital framework present in numerous pharmacologically …

Heme oxygenase-1—Dependent anti-inflammatory effects of atorvastatin in zymosan-injected subcutaneous air pouch in mice

GA El-Achkar, MF Mrad, CA Mouawad, B Badran… - PloS one, 2019 - journals.plos.org
Statins exert pleiotropic and beneficial anti-inflammatory and antioxidant effects. We have
previously reported that macrophages treated with statins increased the expression of heme …

In vitro activity, ultrastructural analysis and in silico pharmacokinetic properties (ADMET) of thiazole compounds against adult worms of Schistosoma mansoni

DVSP da Silva, PH do Bomfim Nascimento… - Acta Tropica, 2023 - Elsevier
The present work aimed to carry out in vitro biological assays of thiazole compounds against
adult worms of Schistosoma mansoni, as well as the in silico determination of …