Flavonoids as anticancer agents

DM Kopustinskiene, V Jakstas, A Savickas… - Nutrients, 2020 - mdpi.com
Flavonoids are polyphenolic compounds subdivided into 6 groups: isoflavonoids,
flavanones, flavanols, flavonols, flavones and anthocyanidins found in a variety of plants …

Flavonoids in cancer and apoptosis

M Abotaleb, SM Samuel, E Varghese, S Varghese… - Cancers, 2018 - mdpi.com
Cancer is the second leading cause of death globally. Although, there are many different
approaches to cancer treatment, they are often painful due to adverse side effects and are …

Neuroprotective effects of anthocyanins and its major component cyanidin-3-O-glucoside (C3G) in the central nervous system: An outlined review

J Zhang, J Wu, F Liu, L Tong, Z Chen, J Chen… - European journal of …, 2019 - Elsevier
Anthocyanins, a class of water soluble flavonoids extracted from plants like berries and
soybean seed, have been shown to display obvious anti-oxidative, anti-inflammatory, and …

The involvement of natural polyphenols in molecular mechanisms inducing apoptosis in tumor cells: A promising adjuvant in cancer therapy

A Chimento, A De Luca, M D'Amico… - International Journal of …, 2023 - mdpi.com
Various literature data show how a diet rich in vegetables could reduce the incidence of
several cancers due to the contribution of the natural polyphenols contained in them …

Anticancer mechanism of flavonoids on high-grade adult-type diffuse gliomas

SC Wong, MNA Kamarudin, R Naidu - Nutrients, 2023 - mdpi.com
High-grade adult-type diffuse gliomas are the most common and deadliest malignant adult
tumors of the central nervous system. Despite the advancements in the multimodality …

3D‐QSAR, molecular docking, molecular dynamics, and ADME/T analysis of marketed and newly designed flavonoids as inhibitors of Bcl‐2 family proteins for …

A Poustforoosh, S Faramarz… - Journal of Cellular …, 2022 - Wiley Online Library
Glioblastoma is the most common and destructive brain tumor with increasing complexity.
Flavonoids are versatile natural compounds with the approved anticancer activity, which …

Cyanidin‐3‐glucoside attenuates the angiogenesis of breast cancer via inhibiting STAT3/VEGF pathway

X Ma, S Ning - Phytotherapy research, 2019 - Wiley Online Library
Angiogenesis plays a pivotal role in breast cancer progression. Cyanidin‐3‐glucoside
(C3G), one of the most widely distributed anthocyanins in edible fruits, shows antioxidative …

The ameliorating effects of anthocyanins on the cross-linked signaling pathways of cancer dysregulated metabolism

S Fakhri, M Khodamorady, M Naseri, MH Farzaei… - Pharmacological …, 2020 - Elsevier
Cancer cells underlie the dysregulated metabolism of carbohydrate, lipid and protein and
thereby, employ interconnected cross-linked signaling pathways to supply adequate energy …

Functional anthocyanin-rich sausages diminish colorectal cancer in an animal model and reduce pro-inflammatory bacteria in the intestinal microbiota

J Fernández, L García, J Monte, CJ Villar, F Lombó - Genes, 2018 - mdpi.com
Colorectal cancer is the fourth most common neoplasia in Europe, where it accounts for 28.2
new cases per 100,000 inhabitants. In an effort to decrease the incidence of this disease …

[HTML][HTML] Bioactive compounds from Actinidia arguta fruit as a new strategy to fight glioblastoma

C Macedo, PC Costa, F Rodrigues - Food Research International, 2024 - Elsevier
In recent years, there has been a significant demand for natural products as a mean of
disease prevention or as an alternative to conventional medications. The driving force for …