Programmed cell death (PCD) is an evolutionarily conserved contributor to nervous system
development. In the vertebrate peripheral nervous system, PCD is the basis of the …

Retinal ganglion cell (RGC) death is the principal consequence of injury to the optic nerve.
For several decades, we have understood that the RGC death process was executed by …

More than half of the initially-formed neurons are deleted in certain brain regions during
normal development. This process, whereby cells are discretely removed without interfering …

The association of more than 140 genes with human photoreceptor degenerations, together
with studies of animal models of these monogenic diseases, has provided great insight into …

Identifying the trophic factors for retina photoreceptors and the intracellular pathways
activated to promote cell survival is crucial for treating retina neurodegenerative diseases …

Glutamate excitotoxicity plays a major role in the loss of retinal ganglion cells (RGCs) in
glaucoma. The toxic effects of glutamate on RGCs are mediated by the overstimulation of N …

Mutations in humans are associated with several forms of inherited retinal dystrophies, such
as Retinitis Pigmentosa which lead to retinal cell death and irreversible loss of vision. Genes …

Despite mounting evidence that the mammalian retina is exceptionally reliant on proper
NAD+ homeostasis for health and function, the specific roles of subcellular NAD+ pools in …

Ceramide (Cer) has a key role inducing cell death and has been proposed as a messenger
in photoreceptor cell death in the retina. Here, we explored the pathways induced by C 2 …

Signal transducers and activators of transcription 3 (STAT 3) play a critical role in
inflammation, proliferation and carcinogenesis. Inhibition of JAK‐STAT 3 signaling is proved …