Epistasis and adaptation on fitness landscapes
C Bank - Annual Review of Ecology, Evolution, and Systematics, 2022 - annualreviews.org
Epistasis occurs when the effect of a mutation depends on its carrier's genetic background.
Despite increasing evidence that epistasis for fitness is common, its role during evolution is …
Despite increasing evidence that epistasis for fitness is common, its role during evolution is …
Evolution in the light of fitness landscape theory
By formalizing the relationship between genotype or phenotype and fitness, fitness
landscapes harbor information on molecular and evolutionary constraints. The shape of the …
landscapes harbor information on molecular and evolutionary constraints. The shape of the …
On the (un) predictability of a large intragenic fitness landscape
C Bank, S Matuszewski, RT Hietpas… - Proceedings of the …, 2016 - National Acad Sciences
The study of fitness landscapes, which aims at mapping genotypes to fitness, is receiving
ever-increasing attention. Novel experimental approaches combined with next-generation …
ever-increasing attention. Novel experimental approaches combined with next-generation …
Predictable properties of fitness landscapes induced by adaptational tradeoffs
Fitness effects of mutations depend on environmental parameters. For example, mutations
that increase fitness of bacteria at high antibiotic concentration often decrease fitness in the …
that increase fitness of bacteria at high antibiotic concentration often decrease fitness in the …
Mapping a systematic ribozyme fitness landscape reveals a frustrated evolutionary network for self-aminoacylating RNA
Molecular evolution can be conceptualized as a walk over a “fitness landscape”, or the
function of fitness (eg, catalytic activity) over the space of all possible sequences …
function of fitness (eg, catalytic activity) over the space of all possible sequences …
[HTML][HTML] Acceptance of near-natural greenspace management relates to ecological and socio-cultural assigned values among European urbanites
Grasslands are widespread elements of urban greenspace providing recreational,
psychological and aesthetic benefits to city residents. Two urban grassland types of …
psychological and aesthetic benefits to city residents. Two urban grassland types of …
The highly rugged yet navigable regulatory landscape of the bacterial transcription factor TetR
Transcription factor binding sites (TFBSs) are important sources of evolutionary innovations.
Understanding how evolution navigates the sequence space of such sites can be achieved …
Understanding how evolution navigates the sequence space of such sites can be achieved …
Machine learning-assisted discovery of growth decision elements by relating bacterial population dynamics to environmental diversity
H Aida, T Hashizume, K Ashino, BW Ying - Elife, 2022 - elifesciences.org
Microorganisms growing in their habitat constitute a complex system. How the individual
constituents of the environment contribute to microbial growth remains largely unknown. The …
constituents of the environment contribute to microbial growth remains largely unknown. The …
Molecular fitness landscapes from high-coverage sequence profiling
The function of fitness (or molecular activity) in the space of all possible sequences is known
as the fitness landscape. Evolution is a random walk on the fitness landscape, with a bias …
as the fitness landscape. Evolution is a random walk on the fitness landscape, with a bias …
Key issues review: evolution on rugged adaptive landscapes
Adaptive landscapes represent a mapping between genotype and fitness. Rugged adaptive
landscapes contain two or more adaptive peaks: allele combinations with higher fitness than …
landscapes contain two or more adaptive peaks: allele combinations with higher fitness than …