Over the past decade, CRISPR has become as much a verb as it is an acronym,
transforming biomedical research and providing entirely new approaches for dissecting all …

Cellular immunotherapies represent a promising approach for the treatment of cancer.
Engineered adoptive cell therapies redirect and augment a leukocyte's inherent ability to …

Despite tumor-associated macrophages (TAMs) playing a key role in shaping the tumor
microenvironment (TME), the mechanisms by which TAMs influence the TME and contribute …

Macrophages are essential innate immune cells found throughout the body that have
protective and pathogenic functions in many diseases. When activated, macrophages can …

Endomembrane damage represents a form of stress that is detrimental for eukaryotic cells,.
To cope with this threat, cells possess mechanisms that repair the damage and restore …

Cell-type-specific in vivo delivery of genome editing molecules is the next breakthrough that
will drive biological discovery and transform the field of cell and gene therapy. Here, we …

ATG5 is a part of the E3 ligase directing lipidation of ATG8 proteins, a process central to
membrane atg8ylation and canonical autophagy. Loss of Atg5 in myeloid cells causes early …

Mutations in the death receptor FAS, or its ligand FASL cause autoimmune
lymphoproliferative syndrome, whereas mutations in caspase-8 or its adaptor FADD—which …

Pathogens use virulence factors to inhibit the immune system. The guard hypothesis,
postulates that hosts monitor (or 'guard') critical innate immune pathways such that their …

During erythroid differentiation, the maintenance of genome integrity is key for the success of
multiple rounds of cell division. However, molecular mechanisms coordinating the …