Dysfunction of the serotonin 1A receptor (5-HT1A) may play a role in the genesis of major
depressive disorder (MDD). Here we review the pharmacological, post-mortem, positron …

Among psychiatric disorders, depression and generalized anxiety are probably the most
common stress-related illnesses. These diseases are underlain, at least partly, by …

Altered inflammatory cytokine profiles are often observed in individuals suffering from major
depression. Recent clinical work reports on elevated IL-6 and decreased IL-10 in …

Despite the knowledge that women are more susceptible than men to stress-related mental
illness, such as major depression, there is no comprehensive estimation of the role of …

A dysregulated hypothalamic-pituitary-adrenal axis (HPA) has been implicated in major
depressive disorder and most commonly used animal models of depression have been …

Emerging evidence indicates that ingestion of specific probiotics, known as “psychobiotics”,
confer beneficial effects on mental health. This study investigated antidepressant-like effects …

Among the central goals of stress neurobiology research is to understand the mechanisms
by which stressors change neural circuit function to precipitate or exacerbate psychiatric …

Glucocorticoids are secreted in discrete pulses resulting in an ultradian rhythm in all species
that have been studied. In the rat there is an approximately hourly rhythm of corticosterone …

Rosemary, Rosmarinus officinalis L.(Labiatae) has several therapeutic applications in folk
medicine in curing or managing a wide range of diseases, including depression. In this …

Enhanced activity of the hypothalamic-pituitary-adrenal (HPA) axis, involving elevated
secretion of corticotropin-releasing hormone (CRH), is considered a key neurobiological …