Most patients who die of cancer have disseminated disease that has become resistant to
multiple therapeutic modalities. Ample evidence suggests that the expression of ATP …

The cystic fibrosis transmembrane conductance regulator (CFTR) belongs to the ATP
binding cassette (ABC) transporter superfamily but functions as an anion channel crucial for …

Cystic fibrosis (CF) is caused by mutations in the cystic fibrosis transmembrane conductance
regulator (CFTR) gene and remains one of the most common life-shortening genetic …

Redox biochemistry is increasingly recognized as an integral component of cellular signal
processing and cell fate decision making. Unfortunately, our capabilities to observe and …

Cystic fibrosis (CF) is caused by mutations in the CF transmembrane conductance regulator
(CFTR). Newly developed “correctors” such as lumacaftor (VX-809) that improve CFTR …

Mutations in the gene coding for the cystic fibrosis transmembrane conductance regulator
(CFTR) epithelial anion channel cause cystic fibrosis (CF). The multidomain integral …

Cystic fibrosis (CF) is a fatal genetic disease caused by mutations in cftr, a gene encoding a
PKA-regulated Cl− channel. The most common mutation results in a deletion of …

Chloride channels represent a relatively under-explored target class for drug discovery as
elucidation of their identity and physiological roles has lagged behind that of many other …

The most common cause of cystic fibrosis (CF) is deletion of phenylalanine 508 (ΔF508) in
the CF transmembrane conductance regulator (CFTR) chloride channel. The ΔF508 …

Rhodanines, thiazolidine-2, 4-diones and pseudothiohydantoins have become a very
interesting class of heterocyclic compounds since the introduction of various glitazones and …