Platelet-derived growth factors (PDGF) promotes cell proliferation, survival and migration,
primarily of cells of mesenchymal origin. Dysfunction of PDGF signaling has been observed …

Fibrosis is an intrinsic response to chronic injury, maintaining organ integrity when extensive
necrosis or apoptosis occurs. With protracted damage, fibrosis can progress toward …

Fibrosis is part of a tissue repair response to injury, defined as increased deposition of
extracellular matrix. In some instances, fibrosis is beneficial; however, in the majority of …

The action of transforming-growth-factor (TGF)-β following inflammatory responses is
characterized by increased production of extracellular matrix (ECM) components, as well as …

In liver tissue matrix metalloproteinases (MMPs) and their specific inhibitors (tissue inhibitors
of metalloproteinases, TIMPs) play a pivotal role in both, fibrogenesis and fibrolysis. The …

Liver fibrosis resulting from chronic liver injury are major causes of morbidity and mortality
worldwide. Among causes of hepatic fibrosis, viral infection is most common (hepatitis B and …

Platelet derived growth factor (PDGF) signaling plays an important role in activated hepatic
stellate cells and portal fibroblast proliferation, chemotaxis, migration and cell survival …

Portal hypertension accounts for the majority of morbidity and mortality that is encountered in
patients with cirrhosis. Portal hypertension is initiated in large part through increases in …

Long-term exposure to arsenic, a widely distributed environmental toxicant, may result in
damage to various organs, including the liver. Mice exposed chronically to arsenite …

Background & Aims Platelet-derived growth factor-β (PDGFB) is a mitogen for hepatic
stellate cells (HSCs). We studied the cellular sources of PDGFB and the effects of a high …