Background The glucagon-like peptide-1 (GLP-1) is a multifaceted hormone with broad
pharmacological potential. Among the numerous metabolic effects of GLP-1 are the glucose …

In the last two decades we have witnessed sizable progress in defining the role of
gastrointestinal signals in the control of glucose and energy homeostasis. Specifically, the …

Incretins are gut hormones that are secreted from enteroendocrine cells into the blood within
minutes after eating. One of their many physiological roles is to regulate the amount of …

The initial identification of glucagon as a counter-regulatory hormone to insulin revealed this
hormone to be of largely singular physiological and pharmacological purpose. Glucagon …

The pituitary adenylate cyclase-activating polypeptide (PACAP)/glucagon superfamily
includes nine hormones in humans that are related by structure, distribution (especially the …

While insulin has long been known to modulate intracellular metabolism by altering the
activity or intracellular location of various enzymes, it is only in the past 10 years that the …

Summary 2022 corresponds to the 100th anniversary of the discovery of glucagon. This
TimeCapsule aims to recall the main steps leading to the discovery, characterisation, and …

Since the relationship between TCF7L2 (also known as TCF-4) polymorphisms and type 2
diabetes mellitus was identified in 2006, extensive genome-wide association examinations …

The WNT signalling pathway is involved in many physiological and pathophysiological
activities. WNT ligands bind to Frizzled receptors and co-receptors (LDL receptor-related …

Discovered almost simultaneously with insulin, glucagon is a pleiotropic hormone with
metabolic action that goes far beyond its classical role to increase blood glucose. Albeit best …