Lipid Trolling to Optimize A3 Adenosine Receptor-Positive Allosteric Modulators (PAMs)
A3 adenosine receptor (A3AR) positive allosteric modulators (PAMs)(2, 4-disubstituted-1 H-
imidazo [4, 5-c] quinolin-4-amines) allosterically increase the E max of A3AR agonists, but …
imidazo [4, 5-c] quinolin-4-amines) allosterically increase the E max of A3AR agonists, but …
Selective modulation of epileptic tissue by an adenosine A3 receptor‐activating drug
A Ghosh, L Ribeiro‐Rodrigues… - British Journal of …, 2024 - Wiley Online Library
Abstract Background and Purpose Adenosine, through the A1 receptor (A1R), is an
endogenous anticonvulsant. The development of adenosine receptor agonists as …
endogenous anticonvulsant. The development of adenosine receptor agonists as …
[HTML][HTML] The Bifunctional Dimer Caffeine-Indan Attenuates α-Synuclein Misfolding, Neurodegeneration and Behavioral Deficits after Chronic Stimulation of Adenosine …
We previously found that chronic adenosine A1 receptor stimulation with N6-
Cyclopentyladenosine increased α-synuclein misfolding and neurodegeneration in a novel …
Cyclopentyladenosine increased α-synuclein misfolding and neurodegeneration in a novel …
2-Amino-5-arylethynyl-thiophen-3-yl-(phenyl)methanones as A1 Adenosine Receptor Positive Allosteric Modulators
A1 adenosine receptor (A1AR) agonists have cerebroprotective, cardioprotective,
antinociceptive, and other pharmaceutical applications. We explored the structure–activity …
antinociceptive, and other pharmaceutical applications. We explored the structure–activity …
2-Aryladenine Derivatives as a Potent Scaffold for Adenosine Receptor Antagonists: The 6-Morpholino Derivatives
F Areias, C Correia, A Rocha, S Teixeira, M Castro… - Molecules, 2024 - mdpi.com
A set of 2-aryl-9-H or methyl-6-morpholinopurine derivatives were synthesized and assayed
through radioligand binding tests at human A1, A2A, A2B, and A3 adenosine receptor …
through radioligand binding tests at human A1, A2A, A2B, and A3 adenosine receptor …
Problems and prospects for finding new pharmacological agents among adenosine receptor agonists, antagonists, or their allosteric modulators for the treatment of …
VN Perfilova, EA Muzyko, AS Taran… - Biomeditsinskaya …, 2023 - pbmc.ibmc.msk.ru
A1-adenosine receptors (A1AR) are widely distributed in the human body and mediate
many different effects. They are abundantly present in the cardiovascular system, where they …
many different effects. They are abundantly present in the cardiovascular system, where they …
Проблемы и перспективы поиска новых фармакологических средств для лечения сердечно-сосудистых заболеваний среди агонистов, антагонистов и …
ВН Перфилова, ЕА Музыко, АС Таран… - Биомедицинская …, 2023 - pbmc.ibmc.msk.ru
А1-аденозиновые рецепторы широко распространены в организме человека и
опосредуют множество разнообразных эффектов. Значительное их количество …
опосредуют множество разнообразных эффектов. Значительное их количество …
Selective modulation of epileptic tissue by an adenosine A3 receptor-activating drug
AM Sebastião, A Ghosh, L Ribeiro-Rodrigues… - ESS Open Archive …, 2024 - authorea.com
Background and Purpose Adenosine, through the A1 receptor (A1R), is an endogenous
anticonvulsant. Development of adenosine receptor agonists as antiseizure medications has …
anticonvulsant. Development of adenosine receptor agonists as antiseizure medications has …