Models of glucose metabolism are a valuable tool for fundamental and applied medical
research in diabetes. Use cases range from pharmaceutical target selection to automatic …

Background: The utility of simulation environments in the development of an artificial
pancreas for type 1 diabetes mellitus (T1DM) management is well established. The …

This paper proposes an optimized control policy over type one diabetes. Type one diabetes
is taken into consideration as a nonlinear model (Augmented Minimal Model), which is …

The controllability and observability of a glucose insulin system is checked for the Sturis–
Tolic model and its modified form for a type 1 diabetic patient. This technique plays a vital …

The dual-hormone artificial pancreas is an emerging technology to treat type 1 diabetes
(T1D). It consists of a glucose sensor, infusion pumps, and a dosing algorithm that directs …

This paper presents the results of a computational study that compares simulated
compartmental (differential equation) and Volterra models of the dynamic effects of insulin …

Abstract Type 1 Diabetes Mellitus (T1DM) remains as a severe public health problem in a
wide range of population, from children to adults. Recently, the number of diabetics …

Background: Insulin-induced hypoglycemia is as a critical barrier in the treatment of type 1
diabetes mellitus patients and may lead to unconsciousness, brain damage, or even death …

Diabetes is a group of metabolic diseases characterized by the inability of the organism to
autonomously regulate the blood glucose levels. It requires continuing medical care to …

In this paper a closed-loop control algorithm for blood glucose regulation in type 1 diabetic
patients is proposed by using the Mamdani-type fuzzy method. Because of the presence of …