Major depressive disorder is a highly debilitating psychiatric disorder involving the
dysfunction of different cell types in the brain. Microglia are the predominant resident …

Accelerated TMS is an emerging application of Transcranial Magnetic Stimulation (TMS)
aimed to reduce treatment length and improve response time. Extant literature generally …

Ketamine treatment decreases depressive symptoms within hours, but the mechanisms
mediating these rapid antidepressant effects are unclear. Here, we demonstrate that activity …

The gut microbiome has been shown to regulate the development and functions of the
enteric and central nervous systems. Its involvement in the regulation of behavior has …

BackgroundThe neuropharmacological actions of antidepressants are well characterised
but our understanding of how these changes translate into improved mood are still …

Major depression is a debilitating and recurrent disorder with a substantial lifetime risk and a
high social cost. Depressed patients generally display co-morbid symptoms, and depression …

Introduction The microbiota-gut-brain axis is a term that is commonly used and covers a
broad set of functions and interactions between the gut microbiome, endocrine, immune and …

Depression is a leading cause of disability worldwide and improving its treatment is a core
research priority for future programmes. A change in the view of psychological and …

Abstract Rationale Serotonin reuptake inhibitors (SSRIs) are effective in treating depression.
Given the existence of different families and subtypes of 5-HT receptors, multiple 5-HT …

Abstract (R, S)-ketamine (ketamine) and its enantiomer (S)-ketamine (esketamine) can
produce rapid and substantial antidepressant effects. However, individual response to …