Nitrogen containing heterocycles as anticancer agents: a medicinal chemistry perspective
Cancer is one of the major healthcare challenges across the globe. Several anticancer
drugs are available on the market but they either lack specificity or have poor safety, severe …
drugs are available on the market but they either lack specificity or have poor safety, severe …
Pyridine: the scaffolds with significant clinical diversity
The nitrogen-bearing heterocycle pyridine in its several analogous forms occupies an
important position as a precious source of clinically useful agents in the field of medicinal …
important position as a precious source of clinically useful agents in the field of medicinal …
Caspase‐3: A primary target for natural and synthetic compounds for cancer therapy
Caspases, a group of protease enzymes (cysteine proteases), exist as inactive zymogens in
the cells and execute apoptosis (programmed cell death). Caspase‐3, an executioner …
the cells and execute apoptosis (programmed cell death). Caspase‐3, an executioner …
A review: Biologically active 3, 4-heterocycle-fused coumarins
The combination of heterocycles offers a new opportunity to create novel multicyclic
compounds having improved biological activity. Coumarins are ubiquitous natural …
compounds having improved biological activity. Coumarins are ubiquitous natural …
[HTML][HTML] Synthesis, in vitro thymidine phosphorylase inhibitory activity and molecular docking study of novel pyridine-derived bis-oxadiazole bearing bis-schiff base …
The current study has afforded twelve analogs (4a-l) of pyridine-derived bis-oxadiazole
containing bis-schiff base and subsequently evaluated for their potential to inhibit thymidine …
containing bis-schiff base and subsequently evaluated for their potential to inhibit thymidine …
Design, synthesis, in vitro biological assessment and molecular modeling insights for novel 3-(naphthalen-1-yl)-4, 5-dihydropyrazoles as anticancer agents with …
Currently, the humanity is in a fierce battle against various health-related challenges
especially those associated with human malignancies. This created the urge to develop …
especially those associated with human malignancies. This created the urge to develop …
Multitargeted platinum (IV) anticancer complexes bearing pyridinyl ligands as axial leaving groups
Although multitargeted PtIV anticancer prodrugs have shown significant activities in
reducing drug resistance, the types of bioactive ligands and drugs that can be conjugated to …
reducing drug resistance, the types of bioactive ligands and drugs that can be conjugated to …
Medicinal attributes of pyridine scaffold as anticancer targeting agents
EA Mohamed, NSM Ismail, M Hagras… - Future Journal of …, 2021 - Springer
Background The heterocyclic compounds particularly pyridine displayed clinical and
biological implementation. Pyridine scaffolds have been detected in most relevant drug …
biological implementation. Pyridine scaffolds have been detected in most relevant drug …
Phytochemistry and Anticancer Effects of Mangrove (Rhizophora mucronata Lam.) Leaves and Stems Extract against Different Cancer Cell Lines
AMM Youssef, DAM Maaty, YM Al-Saraireh - Pharmaceuticals, 2022 - mdpi.com
The biologically active components of the methanol extracts of R. mucronata were identified
using GC/MS. The anticancer effects of each methanol extract from the leaves and stem …
using GC/MS. The anticancer effects of each methanol extract from the leaves and stem …
Anti-corrosion performance of 2-isonicotinoyl-n-phenylhydrazinecarbothioamide for mild steel hydrochloric acid solution: Insights from experimental measurements …
AA Al-Amiery - Surface Review and Letters, 2021 - World Scientific
The corrosion inhibition performance of novel synthesized thiosemicarbazide derivative
namely, 2-isonicotinoyl-N-phenylhydrazinecarbothioamide (IPC) on the mild steel coupon …
namely, 2-isonicotinoyl-N-phenylhydrazinecarbothioamide (IPC) on the mild steel coupon …