Genome-wide association studies
Genome-wide association studies (GWAS) test hundreds of thousands of genetic variants
across many genomes to find those statistically associated with a specific trait or disease …
across many genomes to find those statistically associated with a specific trait or disease …
A cross-population atlas of genetic associations for 220 human phenotypes
Current genome-wide association studies do not yet capture sufficient diversity in
populations and scope of phenotypes. To expand an atlas of genetic associations in non …
populations and scope of phenotypes. To expand an atlas of genetic associations in non …
Current status, issues and future prospects of personalized medicine for each disease
Y Yamamoto, N Kanayama, Y Nakayama… - Journal of Personalized …, 2022 - mdpi.com
In recent years, with the advancement of next-generation sequencing (NGS) technology,
gene panel tests have been approved in the field of cancer diseases, and approaches to …
gene panel tests have been approved in the field of cancer diseases, and approaches to …
Large-scale genome-wide association study in a Japanese population identifies novel susceptibility loci across different diseases
The overwhelming majority of participants in current genetic studies are of European
ancestry. To elucidate disease biology in the East Asian population, we conducted a …
ancestry. To elucidate disease biology in the East Asian population, we conducted a …
DOCK2 is involved in the host genetics and biology of severe COVID-19
H Namkoong, R Edahiro, T Takano, H Nishihara… - Nature, 2022 - nature.com
Identifying the host genetic factors underlying severe COVID-19 is an emerging challenge,,,–
. Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of …
. Here we conducted a genome-wide association study (GWAS) involving 2,393 cases of …
Bioinformatic prediction of potential T cell epitopes for SARS-Cov-2
K Kiyotani, Y Toyoshima, K Nemoto… - Journal of human …, 2020 - nature.com
To control and prevent the current COVID-19 pandemic, the development of novel vaccines
is an emergent issue. In addition, we need to develop tools that can measure/monitor T-cell …
is an emergent issue. In addition, we need to develop tools that can measure/monitor T-cell …
Metagenome-wide association study of gut microbiome revealed novel aetiology of rheumatoid arthritis in the Japanese population
T Kishikawa, Y Maeda, T Nii, D Motooka… - Annals of the …, 2020 - ard.bmj.com
Objective The causality and pathogenic mechanism of microbiome composition remain
elusive in many diseases, including autoimmune diseases such as rheumatoid arthritis (RA) …
elusive in many diseases, including autoimmune diseases such as rheumatoid arthritis (RA) …
A high-resolution HLA reference panel capturing global population diversity enables multi-ancestry fine-mapping in HIV host response
Fine-mapping to plausible causal variation may be more effective in multi-ancestry cohorts,
particularly in the MHC, which has population-specific structure. To enable such studies, we …
particularly in the MHC, which has population-specific structure. To enable such studies, we …
A deep learning method for HLA imputation and trans-ethnic MHC fine-mapping of type 1 diabetes
Conventional human leukocyte antigen (HLA) imputation methods drop their performance
for infrequent alleles, which is one of the factors that reduce the reliability of trans-ethnic …
for infrequent alleles, which is one of the factors that reduce the reliability of trans-ethnic …
Multi-ancestry meta-analysis and fine-mapping in Alzheimer's disease
J Lake, C Warly Solsberg, JJ Kim, J Acosta-Uribe… - Molecular …, 2023 - nature.com
Genome-wide association studies (GWAS) of Alzheimer's disease are predominantly carried
out in European ancestry individuals despite the known variation in genetic architecture and …
out in European ancestry individuals despite the known variation in genetic architecture and …