A review on enzyme complexes of electron transport chain from Mycobacterium tuberculosis as promising drug targets
P Anand, Y Akhter - International journal of biological macromolecules, 2022 - Elsevier
Energy metabolism is a universal process occurring in all life forms. In Mycobacterium
tuberculosis (Mtb), energy production is carried out in two possible ways, oxidative …
tuberculosis (Mtb), energy production is carried out in two possible ways, oxidative …
Impact of binary/ternary solid dispersion utilizing poloxamer 188 and TPGS to improve pharmaceutical attributes of bedaquiline fumarate
VP Pardhi, K Jain - Journal of Drug Delivery Science and Technology, 2021 - Elsevier
Bedaquiline fumarate (BDQN) is approved in year 2012 to treat multidrug resistance
tuberculosis (MDR-TB) through accelerated approval pathway by FDA. It belongs to class II …
tuberculosis (MDR-TB) through accelerated approval pathway by FDA. It belongs to class II …
Bedaquiline Fumarate Microemulsion: Formulation Optimization, Rheological Characterization and In Vitro Studies
Aim: Bedaquiline fumarate (BQF), an antitubercular drug, shows limited bioavailability due to
solubility-limited intestinal absorption. In this research, the authors formulated a BQF-loaded …
solubility-limited intestinal absorption. In this research, the authors formulated a BQF-loaded …
Recent insights into the structure and function of mycobacterial membrane proteins facilitated by Cryo-EM
Mycobacterium tuberculosis (Mtb) is one of the deadliest pathogens encountered by
humanity. Over the decades, its characteristic membrane organization and composition …
humanity. Over the decades, its characteristic membrane organization and composition …
Development of Bedaquiline-Loaded SNEDDS Using Quality by Design (QbD) Approach to Improve Biopharmaceutical Attributes for the Management of Multidrug …
Background: The ever-growing emergence of antibiotic resistance associated with
tuberculosis (TB) has become a global challenge. In 2012, the USFDA gave expedited …
tuberculosis (TB) has become a global challenge. In 2012, the USFDA gave expedited …
[HTML][HTML] A second shell residue modulates a conserved ATP-binding site with radically different affinities for ATP
A Krah, B van der Hoeven, L Mestrom, F Tonin… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Background Prediction of ligand binding and design of new function in enzymes is a time-
consuming and expensive process. Crystallography gives the impression that proteins adopt …
consuming and expensive process. Crystallography gives the impression that proteins adopt …
Response to “Molecular-level understanding of biological energy coupling and transduction: Response to “Chemiosmotic misunderstandings””
PJ Silva - Biophysical Chemistry, 2021 - Elsevier
The most recent contribution by Sunil Nath in these pages is, mostly, a repetition of his
previous claims regarding failures of the chemiosmotic hypotheses, supplemented with …
previous claims regarding failures of the chemiosmotic hypotheses, supplemented with …
Subunit epsilon of E. coli F1Fo ATP synthase attenuates enzyme activity by modulating central stalk flexibility
ABSTRACT F1Fo ATP synthase functions as a biological rotary generator that makes a
major contribution to cellular energy production. Proton flow through the Fo motor generates …
major contribution to cellular energy production. Proton flow through the Fo motor generates …