Aberrant activation of the Wnt signaling pathway is a major trait of many human cancers.
Due to its vast implications in tumorigenesis and progression, the Wnt pathway has attracted …

Aberrant activation of the Wnt pathway is emerging as a frequent event during prostate
cancer that can facilitate tumor formation, progression, and therapeutic resistance. Recent …

Stromal remodeling, in particular fibroblast-to-myofibroblast differentiation, is a hallmark of
benign prostatic hyperplasia (BPH) and solid tumors, including prostate cancer (PCa) …

Antiangiogenic effects of the proteasome inhibitor bortezomib were analyzed on tumor
xenografts in vivo. Bortezomib strongly inhibited angiogenesis and vascularization in the …

Background Prostate cancer is initially dependent on androgens for survival and growth,
making hormonal therapy the cornerstone treatment for late-stage tumors. However, despite …

Background: Dickkopf-related protein 3 (DKK3) is a secreted protein that is involved in the
regulation of cardiac remodeling and vascular smooth muscle cell differentiation, but little is …

Benign prostatic hyperplasia (BPH) is a chronic condition common in older men that can
result in bothersome lower urinary tract symptoms. The molecular mechanisms and …

Disseminated tumor cells (DTCs) undergo a dormant state in the distant metastatic site (s)
before becoming overt metastatic diseases. In prostate cancer (PCa), bone metastasis can …

Aberrant transforming growth factor–β (TGF-β) signaling is a hallmark of the stromal
microenvironment in cancer. Dickkopf-3 (Dkk-3), shown to inhibit TGF-β signaling, is …

Objectives Ovarian cancer is the most lethal gynecological malignancy in North America.
Although survival rates are high when the disease is diagnosed at an early stage, this …