Nuclear magnetic resonance (NMR) spectroscopy is a versatile tool for probing structure,
dynamics, folding, and interactions at atomic resolution. While naturally occurring …

We previously reviewed the use of 19 F NMR in the broad field of chemical biology [Cobb,
SL; Murphy, CD J. Fluorine Chem. 2009, 130, 132–140] and present here a summary of the …

A variety of nuclear magnetic resonance (NMR) applications have been developed for
structure-based drug discovery (SBDD). NMR provides many advantages over other …

19F NMR has emerged as a powerful tool in drug discovery, particularly in fragment-based
screens. The favorable magnetic resonance properties of the fluorine-19 nucleus, the …

Side chain-fluorinated amino acids are useful tools in medicinal chemistry and protein
science. In this review, we outline some general strategies for incorporating fluorine atom (s) …

The fluorination of amino acid residues represents a near-isosteric alteration with the
potential to report on biological pathways, yet the site-directed editing of carbon–hydrogen …

Herein we describe a method for the efficient production (∼ 90% fluorination) of 5-F-Trp
human H ferritin via the selective incorporation of 19 F into the side chain of W93 using 5 …

Protein function is a consequence of a complex and dynamic equilibrium between
allosterically coupled functional states. However, it is often difficult to distinguish the …

Fluorine‐19 NMR spectroscopy has emerged as a powerful tool for studying protein
structure, dynamics, and interactions. Of particular interest is the exploitation of …

Solution NMR spectroscopy plays important roles in understanding protein structures,
dynamics and protein-protein/ligand interactions. In a target-based drug discovery project …