Dynamic metabolism is exhibited by early mammalian embryos to support changing cell
fates during development. It is widely acknowledged that metabolic pathways not only satisfy …

Mitochondria are vital organelles with a central role in all aspects of cellular metabolism. As
a means to support the ever-changing demands of the cell, mitochondria produce energy …

Transposons are mobile genetic elements prevalent in the genomes of most species. The
distribution of transposons within a genome reflects the actions of two opposing processes …

Highly potent animal stem cells either self renew or launch complex differentiation programs,
using mechanisms that are only partly understood. Drosophila female germline stem cells …

The mediation of maternal-embryonic cross-talk via nutrition and metabolism impacts greatly
on offspring health. However, the underlying key interfaces remain elusive. Here, we …

The underlying cellular events driving kidney fibrogenesis and metabolic dysfunction are
incompletely understood. Here, we employed single-cell combinatorial indexing RNA …

In many species, a mother's environment can impact offspring's metabolism, but the
mechanisms that mediate such intergenerational effects are unclear. In this issue, a study …

Cellular quiescence is a dormant, non-dividing cell state characterized by significant shifts in
physiology and metabolism. Quiescence plays essential roles in a wide variety of biological …

In organisms with complex life cycles, life stages that are most susceptible to environmental
stress may determine species persistence in the face of climate change. Early embryos of …

Parental diet is known to influence the offspring in an intergenerational manner, and this has
been implicated in species adaptation and general health. Recent studies highlight the role …