The type 1 insulin‐like growth factor receptor (IGF‐1R) plays an important role in the
establishment and maintenance of the transformed phenotype. It also has a strong …

The type 1 IGF receptor (IGF1R) is a transmembrane tyrosine kinase that is frequently
overexpressed by tumours, and mediates proliferation and apoptosis protection. IGF …

The insulin receptor substrate-1 (IRS-1), a docking protein for both the type 1 insulin-like
growth factor receptor (IGF-IR) and the insulin receptor, is known to send a mitogenic, anti …

The type 1 insulin-like growth factor receptor (IGF-IR) sends several signals, some of which
are contradictory. When the concentrations of insulin receptor substrate 1 (IRS-1), a major …

We show that multiple myeloma (MM), the second most commonly diagnosed hematologic
malignancy, is responsive to hsp90 inhibitors in vitro and in a clinically relevant orthotopic in …

Insulin receptor substrate (IRS) proteins play a central role in maintaining basic cellular
functions such as growth and metabolism. They act as an interface between multiple growth …

Adipocytes can increase in volume up to a thousand-fold, storing excess calories as
triacylglycerol in large lipid droplets. The dramatic morphological changes required of …

This review examines the rationale for targeting the insulin-like growth factor (IGF)-I receptor
in the therapy of human tumours and their metastases. The rationale is based on two crucial …

The insulin-like growth factor 1 receptor (IGF-1R) is a multifunctional receptor that mediates
signals for cell proliferation, differentiation, and survival. Genetic experiments showed that …

MicroRNA-145 (miR-145) is downregulated in various tumor types. However, its mechanism
in inhibiting tumor growth and angiogenesis remains to be elucidated. In this study, we …