The Caenorhabditis elegans Transgenic Toolbox

J Nance, C Frøkjær-Jensen - Genetics, 2019 - academic.oup.com
The power of any genetic model organism is derived, in part, from the ease with which gene
expression can be manipulated. The short generation time and invariant developmental …

[HTML][HTML] Neural signal propagation atlas of Caenorhabditis elegans

F Randi, AK Sharma, S Dvali, AM Leifer - Nature, 2023 - nature.com
Establishing how neural function emerges from network properties is a fundamental problem
in neuroscience. Here, to better understand the relationship between the structure and the …

Connectomes across development reveal principles of brain maturation

D Witvliet, B Mulcahy, JK Mitchell, Y Meirovitch… - Nature, 2021 - nature.com
An animal's nervous system changes as its body grows from birth to adulthood and its
behaviours mature,,,,,,–. The form and extent of circuit remodelling across the connectome is …

Synaptogenesis: unmasking molecular mechanisms using Caenorhabditis elegans

K Mizumoto, Y Jin, JL Bessereau - Genetics, 2023 - academic.oup.com
The nematode Caenorhabditis elegans is a research model organism particularly suited to
the mechanistic understanding of synapse genesis in the nervous system. Armed with …

[HTML][HTML] System-wide mapping of peptide-GPCR interactions in C. elegans

I Beets, S Zels, E Vandewyer, J Demeulemeester… - Cell reports, 2023 - cell.com
Neuropeptides and peptide hormones are ancient, widespread signaling molecules that
underpin almost all brain functions. They constitute a broad ligand-receptor network, mainly …

Brain-wide representations of behavior spanning multiple timescales and states in C. elegans

AA Atanas, J Kim, Z Wang, E Bueno, MC Becker… - Cell, 2023 - cell.com
Changes in an animal's behavior and internal state are accompanied by widespread
changes in activity across its brain. However, how neurons across the brain encode …

Hierarchical recurrent state space models reveal discrete and continuous dynamics of neural activity in C. elegans

S Linderman, A Nichols, D Blei, M Zimmer, L Paninski - BioRxiv, 2019 - biorxiv.org
Modern recording techniques enable large-scale measurements of neural activity in a
variety of model organisms. The dynamics of neural activity shed light on how organisms …

Caenorhabditis elegans sine oculis/SIX-type homeobox genes act as homeotic switches to define neuronal subtype identities

C Cros, O Hobert - Proceedings of the National Academy of …, 2022 - National Acad Sciences
The classification of neurons into distinct types reveals hierarchical taxonomic relationships
that reflect the extent of similarity between neuronal cell types. At the base of such …

Neuropeptide signaling network of Caenorhabditis elegans: from structure to behavior

J Watteyne, A Chudinova, L Ripoll-Sánchez… - Genetics, 2024 - academic.oup.com
Neuropeptides are abundant signaling molecules that control neuronal activity and behavior
in all animals. Owing in part to its well-defined and compact nervous system, Caenorhabditis …

Neuropeptides and behaviors: how small peptides regulate nervous system function and behavioral outputs

US Bhat, N Shahi, S Surendran, K Babu - Frontiers in Molecular …, 2021 - frontiersin.org
One of the reasons that most multicellular animals survive and thrive is because of the
adaptable and plastic nature of their nervous systems. For an organism to survive, it is …