Basal forebrain cholinergic signalling: development, connectivity and roles in cognition

MR Ananth, P Rajebhosale, R Kim… - Nature Reviews …, 2023 - nature.com
Acetylcholine plays an essential role in fundamental aspects of cognition. Studies that have
mapped the activity and functional connectivity of cholinergic neurons have shown that the …

Deciphering inhibitory neuron development: the paths to diversity

RC Bandler, C Mayer - Current Opinion in Neurobiology, 2023 - Elsevier
The regulation of fate decisions in progenitor cells lays the foundation for the generation of
neuronal diversity and the formation of specialized circuits with remarkable processing …

Interneuron origin and molecular diversity in the human fetal brain

Y Yu, Z Zeng, D Xie, R Chen, Y Sha, S Huang… - Nature …, 2021 - nature.com
Precise generation of excitatory neurons and inhibitory interneurons is crucial for proper
formation and function of neural circuits in the mammalian brain. Because of the size and …

Human pallial MGE-type GABAergic interneuron cell therapy for chronic focal epilepsy

M Bershteyn, S Bröer, M Parekh, Y Maury, S Havlicek… - Cell Stem Cell, 2023 - cell.com
Mesial temporal lobe epilepsy (MTLE) is the most common focal epilepsy. One-third of
patients have drug-refractory seizures and are left with suboptimal therapeutic options such …

Spatial enhancer activation influences inhibitory neuron identity during mouse embryonic development

E Dvoretskova, MC Ho, V Kittke, F Neuhaus… - Nature …, 2024 - nature.com
The mammalian telencephalon contains distinct GABAergic projection neuron and
interneuron types, originating in the germinal zone of the embryonic basal ganglia. How …

Critical test of the assumption that the hypothalamic entopeduncular nucleus of rodents is homologous with the primate internal pallidum

L Puelles, T Stühmer, JLR Rubenstein… - Journal of …, 2023 - Wiley Online Library
The globus pallidus (GP) of primates is divided conventionally into distinct internal and
external parts. The literature repeats since 1930 the opinion that the homolog of the primate …

The transcription factor Zfp503 promotes the D1 MSN identity and represses the D2 MSN identity

Z Shang, L Yang, Z Wang, Y Tian, Y Gao… - Frontiers in Cell and …, 2022 - frontiersin.org
The striatum is primarily composed of two types of medium spiny neurons (MSNs)
expressing either D1-or D2-type dopamine receptors. However, the fate determination of …

Cell-type-specific cis-regulatory divergence in gene expression and chromatin accessibility revealed by human-chimpanzee hybrid cells

B Wang, AL Starr, HB Fraser - Elife, 2024 - elifesciences.org
Although gene expression divergence has long been postulated to be the primary driver of
human evolution, identifying the genes and genetic variants underlying uniquely human …

DLX genes and proteins in mammalian forebrain development

JL Rubenstein, AS Nord, M Ekker - Development, 2024 - journals.biologists.com
The vertebrate Dlx gene family encode homeobox transcription factors that are related to the
Drosophila Distal-less (Dll) gene and are crucial for development. Over the last∼ 35 years …

Single-cell sequencing of rodent ventral pallidum reveals diverse neuronal subtypes with non-canonical interregional continuity

DJ Ottenheimer, RC Simon, CT Burke, AJ Bowen… - bioRxiv, 2024 - biorxiv.org
The ventral pallidum (VP) was defined as a basal ganglia nucleus with dense input from
ventral striatum. To further investigate a VP regional identity, we conducted a cross-species …