Highlights•Functional MRI continues to have the potential to play a useful role in developing novel compounds.•But the lack of consensus on optimal techniques for acquisition and …
Repeated measurements and multimodal data are common in neuroimaging research. Despite this, conventional approaches to group level analysis ignore these repeated …
JFW Deakin - Journal of psychopharmacology, 2013 - journals.sagepub.com
In this brief reflection I outline how Fred Graeff and I came to integrate our ideas and findings concerning the behavioural functions of serotonin (5-HT) over 20 years ago in '5-HT and …
D Borsook, L Becerra, M Fava - Translational psychiatry, 2013 - nature.com
The use of novel brain biomarkers using nuclear magnetic resonance imaging holds potential of making central nervous system (CNS) drug development more efficient. By …
TJ Little, S McKie, RB Jones, M D'Amato, C Smith… - Neuroimage, 2014 - Elsevier
Objectives Previous fMRI studies have demonstrated that glucose decreases the hypothalamic BOLD response in humans. However, the mechanisms underlying the CNS …
Pharmacological magnetic resonance imaging (phMRI) is one method by which a drug's pharmacodynamic effects in the brain can be assessed. Although phMRI has been …
Hemopressin is the first peptide ligand to be described for the CB1 cannabinoid receptor. Hemopressin acts as an inverse agonist in vivo and can cross the blood–brain barrier to …
Impaired hippocampal function is believed to be important in the pathogenesis of depression. The hippocampus contains a high concentration of both mineralocorticoid (MR) …