Biomarkers, designs, and interpretations of resting‐state fMRI in translational pharmacological research: A review of state‐of‐the‐Art, challenges, and opportunities for …
N Khalili‐Mahani, SARB Rombouts… - Human brain …, 2017 - Wiley Online Library
A decade of research and development in resting‐state functional MRI (RSfMRI) has
opened new translational and clinical research frontiers. This review aims to bridge between …
opened new translational and clinical research frontiers. This review aims to bridge between …
[HTML][HTML] The role of fMRI in drug development
Highlights•Functional MRI continues to have the potential to play a useful role in developing
novel compounds.•But the lack of consensus on optimal techniques for acquisition and …
novel compounds.•But the lack of consensus on optimal techniques for acquisition and …
Comparing the actions of lanicemine and ketamine in depression: key role of the anterior cingulate
Intravenous infusion of lanicemine (formerly AZD6765), a low trapping non-selective N-
methyl-D-aspartate (NMDA) receptor antagonist, induces antidepressant effects with a …
methyl-D-aspartate (NMDA) receptor antagonist, induces antidepressant effects with a …
[HTML][HTML] Multivariate and repeated measures (MRM): A new toolbox for dependent and multimodal group-level neuroimaging data
Repeated measurements and multimodal data are common in neuroimaging research.
Despite this, conventional approaches to group level analysis ignore these repeated …
Despite this, conventional approaches to group level analysis ignore these repeated …
The origins of '5-HT and mechanisms of defence'by Deakin and Graeff: a personal perspective
JFW Deakin - Journal of psychopharmacology, 2013 - journals.sagepub.com
In this brief reflection I outline how Fred Graeff and I came to integrate our ideas and findings
concerning the behavioural functions of serotonin (5-HT) over 20 years ago in '5-HT and …
concerning the behavioural functions of serotonin (5-HT) over 20 years ago in '5-HT and …
Use of functional imaging across clinical phases in CNS drug development
The use of novel brain biomarkers using nuclear magnetic resonance imaging holds
potential of making central nervous system (CNS) drug development more efficient. By …
potential of making central nervous system (CNS) drug development more efficient. By …
[HTML][HTML] Mapping glucose-mediated gut-to-brain signalling pathways in humans
Objectives Previous fMRI studies have demonstrated that glucose decreases the
hypothalamic BOLD response in humans. However, the mechanisms underlying the CNS …
hypothalamic BOLD response in humans. However, the mechanisms underlying the CNS …
Parallel buprenorphine phMRI responses in conscious rodents and healthy human subjects
Pharmacological magnetic resonance imaging (phMRI) is one method by which a drug's
pharmacodynamic effects in the brain can be assessed. Although phMRI has been …
pharmacodynamic effects in the brain can be assessed. Although phMRI has been …
Central functional response to the novel peptide cannabinoid, hemopressin
GT Dodd, AA Worth, DJ Hodkinson, RK Srivastava… - …, 2013 - Elsevier
Hemopressin is the first peptide ligand to be described for the CB1 cannabinoid receptor.
Hemopressin acts as an inverse agonist in vivo and can cross the blood–brain barrier to …
Hemopressin acts as an inverse agonist in vivo and can cross the blood–brain barrier to …
Detection of the acute effects of hydrocortisone in the hippocampus using pharmacological fMRI
Impaired hippocampal function is believed to be important in the pathogenesis of
depression. The hippocampus contains a high concentration of both mineralocorticoid (MR) …
depression. The hippocampus contains a high concentration of both mineralocorticoid (MR) …