Mechanical force is an essential physical element that contributes to the formation and
function of life. The discovery of the evolutionarily conserved PIEZO family, including PIEZO1 …

Abstract Changes in old age that contribute to the complex issue of an increased metabolic
cost of walking (mass-specific energy cost per unit distance traveled) in older adults appear …

Meniscus is a complex and crucial fibrocartilaginous tissue within the knee joint. Meniscal
regeneration remains to be a scientific and translational challenge. We clarified that …

How mechanical stress affects physical performance via tendons is not fully understood.
Piezo1 is a mechanosensitive ion channel, and E756del PIEZO1 was recently found as a …

Piezo1 channels are essential mechanically activated ion channels in vertebrates. Their
selective activation by the synthetic chemical activator Yoda1 opened new avenues to probe …

The Piezo channel family, including Piezo1 and Piezo2, includes essential
mechanosensitive transduction molecules in mammals. Functioning in the conversion of …

Piezo1 is a recently discovered Ca2+ permeable ion channel that has emerged as an
integral sensor of hemodynamic forces within the cardiovascular system, contributing to …

Tendinopathy is a multi-faceted pathology characterized by alterations in tendon
microstructure, cellularity and collagen composition. Challenged by the possibility of …

PIEZO1 and PIEZO2 are mechanosensitive cation channels that are highly expressed in
numerous tissues throughout the body and exhibit diverse, cell-specific functions in multiple …

Cells integrate mechanical cues to direct fate specification to maintain tissue function and
homeostasis. While disruption of these cues is known to lead to aberrant cell behavior and …