Central nervous system neurons communicate via fast synaptic transmission mediated by
ligand-gated ion channel (LGIC) receptors and slower neuromodulation mediated by G …

Forty years ago, a simple model of allosteric mechanisms (indirect interactions between
distinct sites), used initially to explain feedback-inhibited enzymes, was presented by …

Typically at dawn on a hot summer day, land plants need precise molecular thermometers to
sense harmless increments in the ambient temperature to induce a timely heat shock …

▪ Abstract Cyclic nucleotide–activated ion channels play a fundamental role in a variety of
physiological processes. By opening in response to intracellular cyclic nucleotides, they …

Abstract The Concise Guide to PHARMACOLOGY 2013/14 provides concise overviews of
the key properties of over 2000 human drug targets with their pharmacology, plus links to an …

Plant innate immune response to pathogen infection includes an elegant signaling pathway
leading to reactive oxygen species generation and resulting hypersensitive response (HR); …

Olfaction, the sense of smell detects and discriminate odors as well as social cues which
influence our innate responses. The olfactory system in human beings is found to be weak …

An increased concentration of cytosolic calcium ions (Ca2+) is an early response by plant
cells to heat shock. However, the molecular mechanism underlying the heat‐induced initial …

Viruses initiate infection by attaching to molecules or receptors at the cell surface. Hepatitis
C virus (HCV) enters cells via a multistep process involving tetraspanin CD81, scavenger …

Most vertebrate olfactory receptor neurons share a common G-protein–coupled pathway for
transducing the binding of odorant into depolarization. The depolarization involves 2 …