An important factor in the transition from an open to a closed circulatory system was a
change in vessel wall structure and composition that enabled the large arteries to store and …

Macrophages are the first immune cells in the developing embryo and have a central role in
organ development, homeostasis, immunity and repair. Over the last century, our …

Biomechanical forces are emerging as critical regulators of embryogenesis, particularly in
the developing cardiovascular system,. After initiation of the heartbeat in vertebrates, cells …

The embryonic heart and vessels are dynamic and form and remodel while functional. Much
has been learned about the genetic mechanisms underlying the development of the …

To better understand the relationship between the embryonic hematopoietic and vascular
systems, we investigated the establishment of circulation in mouse embryos by examining …

The genetic basis of heart development is remarkably conserved from Drosophila to
mammals, and insights from flies have greatly informed our understanding of vertebrate …

The relative contribution of yolk sac (YS)–derived cells to the circulating definitive
hematopoietic progenitor cell (HPC) pool that seeds the fetal liver remains controversial due …

The enucleated definitive erythrocytes of mammals are unique in the animal kingdom. The
observation that yolk sac–derived primitive erythroid cells in mammals circulate as …

Steady‐state production of all circulating blood cells in the adult ultimately depends on
hematopoietic stem cells (HSC s), which first arise in small numbers beginning at embryonic …

Erythro-myeloid progenitors (EMP) serve as a major source of hematopoiesis in the
developing conceptus prior to the formation of a permanent blood system. In this review, we …