Epigenetics is dynamic and heritable modifications to the genome that occur independently
of DNA sequence. It requires interactions cohesively with various enzymes and other …

Autophagy is an indispensable mechanism of the eukaryotic cell, facilitating the removal and
renewal of cellular components and thereby balancing the cell's energy consumption and …

Missense mutations in p53 generate aberrant proteins with abrogated tumour suppressor
functions that can also acquire oncogenic gain-of-function activities that promote malignant …

Uterine leiomyosarcoma (uLMS) is the most common subtype of uterine sarcomas. They
have a poor prognosis with high rates of recurrence and metastasis. The five-year survival …

Because the overexpression of histone deacetylase enzymes (HDACs) has been linked to
numerous diseases, including various cancers and neurodegenerative disorders, HDAC …

Histone deacetylase inhibitors (HDACi) are promising anti-cancer agents, however, their
mechanisms of action remain unclear. In acute myeloid leukemia (AML) cells, HDACi have …

Sarcomas are a rare group of malignant tumors originating from mesenchymal stem cells.
Surgery, radiation and chemotherapy are currently the only standard treatments for sarcoma …

Tumor development and progression is the consequence of genetic as well as epigenetic
alterations of the cell. As part of the epigenetic regulatory system, histone acetyltransferases …

Histone deacetylases (HDACs) are responsible for the deacetylation of lysine residues in
histone or non-histone substrates, leading to the regulation of many biological functions …

Glioblastoma multiforme (GBM) is a highly aggressive primary brain tumor associated with
limited treatment options and high drug resistance, presenting significant challenges in the …