The central nervous system (CNS) has the highest concentration of lipids in the organism
after adipose tissue. Among these lipids, the brain is particularly enriched with …

Alzheimer's disease (AD) and other forms of dementia represent major public health
challenges but effective therapeutic options are limited. Pathological brain aging is …

Being characterized by progressive and severe damage in neuronal cells,
neurodegenerative diseases (NDDs) are the major cause of disability and morbidity in the …

Lipids are not only constituents of cellular membranes, but they are also key signaling
mediators, thus acting as “bioactive lipids”. Among the prominent roles exerted by bioactive …

Eicosapentaenoic acid (EPA), an omega-3 fatty acid, has been widely used to prevent
cardiovascular disease (CVD) and treat brain diseases alone or in combination with …

Maternal immune activation (MIA) is a common environmental insult on the developing brain
and represents a risk factor for neurodevelopmental disorders. Animal models of in utero …

Alzheimer's disease (AD) and Parkinson's disease (PD) are neurodegenerative disorders
that affect millions of individuals worldwide. As incidence of these conditions increases with …

After the initiation of inflammation, a series of processes start to resolve the inflammation. A
group of endogenous lipid mediators, namely specialized pro‐resolving lipid mediators is at …

Specialized pro-resolving mediators (SPMs) are lipid mediators derived from poly-
unsaturated fatty acids (PUFAs) which have been demonstrated to have an important role in …

Abstract Docosahexaenoic acid (DHA, 22: 6n-3) accretion in brain phospholipids is critical
for maintaining the structural fluidity that permits proper assembly of protein complexes for …