Diabetic Peripheral Neuropathy: Emerging Treatments of Neuropathic Pain and Novel Diagnostic Methods

J Røikjer, MK Borbjerg, T Andresen… - Journal of Diabetes …, 2024 - journals.sagepub.com
Background: Diabetic peripheral neuropathy (DPN) is a prevalent and debilitating
complication of diabetes, often leading to severe neuropathic pain. Although other diabetes …

[HTML][HTML] Symptom perception in adults with chronic physical disease: A systematic review of insular impairments

G Locatelli, A Matus, CY Lin, E Vellone, B Riegel - Heart & Lung, 2025 - Elsevier
Background To perform self-care, individuals with a chronic illness must be able to perceive
bodily changes (ie., interoception) so they can respond to symptoms when they arise …

[HTML][HTML] Neuropathic phenotypes of type 1 diabetes are related to different signatures of magnetic resonance spectroscopy-assessed brain metabolites

TM Hansen, SS Croosu, J Røikjer, CD Mørch… - Clinical …, 2024 - Elsevier
Objectives The study aimed to investigate brain metabolites in type 1 diabetes and the
associations with disease characteristics. We explored the metabolic profiles predicting …

[HTML][HTML] Quantification of white matter hyperintensities in type 1 diabetes and its relation to neuropathy and clinical characteristics

TM Hansen, SS Croosu, S Kianimehr, M Gjela… - Brain Research, 2025 - Elsevier
Aims The aims were to quantify periventricular and deep white matter hyperintensities
(WMHs) in adults with type 1 diabetes with different neuropathic phenotypes and to correlate …

Cognitive function in individuals with and without painful and painless diabetic polyneuropathy—A cross‐sectional study in type 1 diabetes

SS Croosu, M Gjela, J Røikjer… - Endocrinology …, 2023 - Wiley Online Library
Introduction Previous studies suggest that cognitive impairment is more prevalent in
individuals with painful and painless diabetic peripheral neuropathy (DPN). However, the …

The co-existence of sensory and autonomic neuropathy in type 1 diabetes with and without pain

J Røikjer, SS Croosu, TM Hansen, JB Frøkjær… - Acta Diabetologica, 2023 - Springer
Aims To investigate the co-existence of diabetic peripheral neuropathy (DPN), painful
diabetic peripheral neuropathy (PDPN), and cardiac autonomic neuropathy (CAN) and to …

Higher sensory cortical energy metabolism in painful diabetic neuropathy: evidence from a cerebral magnetic resonance spectroscopy study

G Sloan, A Anton, S Caunt, I Wilkinson, D Selvarajah… - Diabetes, 2023 - Am Diabetes Assoc
Alterations in the resting-state functional connectivity and hyperperfusion of pain processing
areas of the brain have been demonstrated in painful diabetic peripheral neuropathy (DPN) …

[HTML][HTML] Altered surface-based brain morphometry in type 1 diabetes and neuropathic pain

SNF Hostrup, SS Croosu, J Røikjer, CD Mørch… - Neuroscience, 2025 - Elsevier
This study explored surface brain morphometry in type 1 diabetes including focus on painful
diabetic peripheral neuropathy (DPN). Brain MRI was obtained from 56 individuals with …

Optimizing examination time and diagnostic performance of the histamine‐induced axon‐reflex flare response in diabetes

J Røikjer, SS Croosu, MK Borbjerg, TM Hansen… - Muscle & …, 2023 - Wiley Online Library
Abstract Introduction/Aims The axon‐reflex flare response is a reliable method for functional
assessment of small fibers in diabetic peripheral neuropathy (DPN), but broad adoption is …

Magnetic resonance imaging on brain structure and function changes in diabetic peripheral neuropathy

L Wang, J Yue, S Gao, D Cao, A Li, C Peng… - Frontiers in …, 2023 - frontiersin.org
With the significant increase in the global prevalence of diabetes mellitus (DM), the
occurrence of diabetic peripheral neuropathy (DPN) has become increasingly common …