Seeing (and using) the light: recent developments in bioluminescence technology

AC Love, JA Prescher - Cell Chemical Biology, 2020 - cell.com
Bioluminescence has long been used to image biological processes in vivo. This technology
features luciferase enzymes and luciferin small molecules that produce visible light …

Advances in bioluminescence imaging: new probes from old recipes

Z Yao, BS Zhang, JA Prescher - Current opinion in chemical biology, 2018 - Elsevier
Highlights•Advances in bioluminescent tool production that mirror trends in fluorescent
probe development.•New bioluminescent platforms based on naturally occurring luciferases …

Recent achievements of bioluminescence imaging based on firefly luciferin-luciferase system

S Li, Z Ruan, H Zhang, H Xu - European Journal of Medicinal Chemistry, 2021 - Elsevier
Bioluminescence imaging (BLI) is a newly developed noninvasive visual approach which
facilitates the understanding of a plethora of biological processes in vitro and in vivo due to …

Oxidative C–H homocoupling of push–pull benzothiazoles: an atom-economical route to highly emissive quadrupolar arylamine-functionalized 2, 2 …

P Osusky, J Nociarová, M Smolicek, R Gyepes… - Organic …, 2021 - ACS Publications
Copper (II)-catalyzed C–H/C–H coupling of dipolar 2-H-benzothiazoles end-capped with
triphenylamine moieties affords highly fluorescent 2, 2′-bibenzothiazoles with quadrupolar …

Bioluminogenic probe for rapid, ultrasensitive detection of β-lactam-resistant bacteria

T Dai, J Xie, JA Buonomo, A Moreno, N Banaei… - Analytical …, 2023 - ACS Publications
Increasingly difficult-to-treat infections by antibiotic-resistant bacteria have become a major
public health challenge. Rapid detection of common resistance mechanisms before empiric …

Silicon functionalization expands the repertoire of Si-rhodamine fluorescent probes

DN Rao, X Ji, SC Miller - Chemical Science, 2022 - pubs.rsc.org
Fluorescent dyes such as rhodamines are widely used to assay the activity and image the
location of otherwise invisible molecules. Si-rhodamines, in which the bridging oxygen of …

K2S2O8 mediated metal free oxidative coupling of alcohols with 1, 2-diaminobenzenes for synthesis of benzimidazoles, photophysical and DFT studies

P Saha, P Kour, R Kumar, DK Sharma - Journal of Molecular Structure, 2023 - Elsevier
We report the K 2 S 2 O 8 catalyzed oxidative coupling of 1, 2-diaminobenzenes and primary
alcohols for the synthesis of benzimidazoles under metal-free conditions by utilizing oxygen …

The strategy to improve the brightness of organic small-molecule fluorescent dyes for imaging

J Zhou, TB Ren, L Yuan - Chinese Chemical Letters, 2024 - Elsevier
Organic small molecule fluorophores have been widely used in biology and biochemistry to
study cellular structures and processes at high spatial and temporal resolution. Small …

Building Biological Flashlights: Orthogonal Luciferases and Luciferins for in Vivo Imaging

SJ Williams, JA Prescher - Accounts of chemical research, 2019 - ACS Publications
Conspectus Bioluminescence is widely used for real-time imaging in living organisms. This
technology features a light-emitting reaction between enzymes (luciferases) and small …

Azetidine-containing heterospirocycles enhance the performance of fluorophores

J Zhou, X Lin, X Ji, S Xu, C Liu, X Dong, W Zhao - Organic Letters, 2020 - ACS Publications
Fluorescent dyes are extensively utilized in various fluorescence imaging techniques.
However, many existing modification strategies could not balance the performance (such as …