Nano-based eye drop: Topical and noninvasive therapy for ocular diseases

C Wang, Y Pang - Advanced drug delivery reviews, 2023 - Elsevier
Eye drops are the most accessible therapy for ocular diseases, while inevitably suffering
from their lower bioavailability which highly restricts the treatment efficacy. The introduction …

Lab‐on‐a‐Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics

Y Zhu, S Li, J Li, N Falcone, Q Cui, S Shah… - Advanced …, 2022 - Wiley Online Library
The eye is one of the most complex organs in the human body, containing rich and critical
physiological information (eg, intraocular pressure, corneal temperature, and pH) as well as …

CD-MOFs: From preparation to drug delivery and therapeutic application

Y Si, H Luo, P Zhang, C Zhang, J Li, P Jiang… - Carbohydrate …, 2024 - Elsevier
Cyclodextrin metal-organic frameworks (CD-MOFs) show considerable advantages of
edibility, degradability, low toxicity, and high drug loading, which have attracted enormous …

Soft contact lenses as drug delivery systems: a review

I Rykowska, I Nowak, R Nowak - Molecules, 2021 - mdpi.com
This review describes the role of contact lenses as an innovative drug delivery system in
treating eye diseases. Current ophthalmic drug delivery systems are inadequate, particularly …

Smart contact lens systems for ocular drug delivery and therapy

TY Kim, GH Lee, J Mun, S Cheong, I Choi, H Kim… - Advanced Drug Delivery …, 2023 - Elsevier
Ocular drug delivery and therapy systems have been extensively investigated with various
methods including direct injections, eye drops and contact lenses. Nowadays, smart contact …

Carbohydrate polymer-based bioadhesive formulations and their potentials for the treatment of ocular diseases: a review

X Tang, J Liu, R Yan, Q Peng - International Journal of Biological …, 2023 - Elsevier
Eyes are directly exposed to the outer environment and susceptible to infections, leading to
various ocular disorders. Local medication is preferred to treat eye diseases due to its …

Topical drug delivery to the posterior segment of the eye

M Loescher, C Seiz, J Hurst, S Schnichels - Pharmaceutics, 2022 - mdpi.com
Topical drug delivery to the posterior segment of the eye is a very complex challenge.
However, topical delivery is highly desired, to achieve an easy-to-use treatment option for …

Chitosan-coated bovine serum albumin nanoparticles for topical tetrandrine delivery in glaucoma: in vitro and in vivo assessment

SES Radwan, RM El-Moslemany, RA Mehanna… - Drug Delivery, 2022 - Taylor & Francis
Glaucoma is one of the leading causes of blindness. Therapies available suffer from several
drawbacks including low bioavailability, repeated administration and poor patient …

Sustained latanoprost release from PEGylated solid lipid nanoparticle-laden soft contact lens to treat glaucoma

H Dang, C Dong, L Zhang - Pharmaceutical Development and …, 2022 - Taylor & Francis
Contact lens have been proposed as a mean of ocular drug delivery, but the conventional
soaking method to load hydrophobic drugs, such as latanoprost shows low drug loading and …

A tissue-adhesive F127 hydrogel delivers antioxidative copper-selenide nanoparticles for the treatment of dry eye disease

L Ou, Z Wu, X Hu, J Huang, Z Yi, Z Gong, H Li, K Peng… - Acta biomaterialia, 2024 - Elsevier
Dry eye disease (DED) is currently the most prevalent condition seen in ophthalmology
outpatient clinics, representing a significant public health issue. The onset and progression …