Background Traditional risk factors are insufficient to explain all cases of coronary artery
disease (CAD) in patients with diabetes mellitus (DM). Advanced glycation end-products …

There is a global diabetes epidemic correlating with an increase in obesity. This coincidence
may lead to a rise in the prevalence of type 2 diabetes. There is also an as yet unexplained …

In addition to providing a macromolecular scaffold, the extracellular matrix (ECM) is a critical
regulator of cell function by virtue of specific physical, biochemical, and mechanical …

Blood oligosaccharides are attached to many proteins after translation, forming
glycoproteins. Glycosylation refers to an enzyme-mediated modification that alters protein …

Methods For this prospective analysis, we included 72,880 participants of the Dutch Lifelines
Cohort Study, who underwent baseline investigations between 2007 and 2013, had …

Background Multiple pathogenetic mechanisms are involved in the genesis of various
microvascular and macrovascular complications of diabetes mellitus. Of all these, advanced …

Advanced glycation end-products (AGEs) are heterogeneous molecules produced by the
non-enzymatic glycation of proteins, lipids, or nucleic acids during hyperglycaemia …

Advanced glycation endproducts (AGEs), pathophysiological important posttranslational
modifications, are formed in vivo by a non-enzymatic reaction of proteins with reactive …

A non-enzymatic reaction between reducing sugars and the amino groups of proteins, lipids
and nucleic acids is known as the “Maillard reaction”. The reactions have progressed in a …

Objective—Advanced glycation end products play a pivotal role in atherosclerosis. Recently,
we showed that tissue advanced glycation end products deposition, noninvasively assessed …