Membrane trafficking plays a crucial role in cell polarity by directing lipids and proteins to
specific subcellular locations in the cell and sustaining a polarized state. The Golgi …

A tendency in cell biology is to divide and conquer. For example, decades of painstaking
work have led to an understanding of endoplasmic reticulum (ER) and Golgi structure …

Actin filaments play multiple roles in the secretory pathway and in endosome dynamics in
mammals, including maintenance of Golgi structure, release of membrane cargo from the …

Mitochondria are dynamic organelles that undergo cycles of fission and fusion events
depending on cellular requirements. During mitochondrial division, the GTPase dynamin …

Abstract Phosphatidylinositol 4-phosphate (PI4P) is a membrane glycerophospholipid and a
major regulator of the characteristic appearance of the Golgi complex as well as its vesicular …

Members of the myosin superfamily are involved in all aspects of eukaryotic life. Their
function ranges from the transport of organelles and cargos to the generation of membrane …

The actin cytoskeleton, which regulates cell polarity, adhesion, and migration, can influence
cancer progression, including initial acquisition of malignant properties by normal cells …

The C-terminal variants G1 and G2 of apolipoprotein L1 (APOL1) confer human resistance
to the sleeping sickness parasite Trypanosoma rhodesiense, but they also increase the risk …

Vesicle budding for Golgi-to-plasma membrane trafficking is a key step in secretion. Proteins
that induce curvature of the Golgi membrane are predicted to be required, by analogy to …

The Golgi complex is the membrane-bound organelle that lies at the center of the secretory
pathway. Its main functions are to maintain cellular lipid homeostasis, to orchestrate protein …