Reperfusion injury salvage kinase signalling: taking a RISK for cardioprotection

DJ Hausenloy, DM Yellon - Heart failure reviews, 2007 - Springer
Following an acute myocardial infarction (AMI), early coronary artery reperfusion remains
the most effective means of limiting the eventual infarct size. The resultant left ventricular …

Corticotropin releasing factor (CRF) receptor signaling in the central nervous system: new molecular targets

RL Hauger, V Risbrough, O Brauns… - CNS & Neurological …, 2006 - ingentaconnect.com
Corticotropin-releasing factor (CRF) and the related urocortin peptides mediate behavioral,
cognitive, autonomic, neuroendocrine and immunologic responses to aversive stimuli by …

Physiology, pharmacology, and therapeutic relevance of urocortins in mammals: ancient CRF paralogs

ÉM Fekete, EP Zorrilla - Frontiers in neuroendocrinology, 2007 - Elsevier
Urocortins, three paralogs of the stress-related peptide corticotropin-releasing factor (CRF)
found in bony fish, amphibians, birds, and mammals, have unique phylogenies …

Clinical implications of apoptosis in ischemic myocardium

TM Scarabelli, R Knight, A Stephanou… - Current problems in …, 2006 - Elsevier
Apoptosis, a genetically programmed form of cell death, contributes to myocyte cell loss in a
variety of cardiac pathologies, including cardiac failure and those related to …

Cardioprotective growth factors

DJ Hausenloy, DM Yellon - Cardiovascular research, 2009 - academic.oup.com
Many of the originally identified cardiovascular 'growth factors' have been demonstrated to
exert a diverse variety of actions within the cardiovascular system, the majority of which are …

Physiological roles of urocortins, human homologues of fish urotensin I, and their receptors

T Suda, K Kageyama, S Sakihara, T Nigawara - Peptides, 2004 - Elsevier
Urocortin 1, a human homologue of fish urotensin I, together with its related-compounds
(urocortins 2 and 3), comprises a distinct family of stress peptides. Urocortin 1 has a high …

Adenosine triggers preconditioning through MEK/ERK1/2 signalling pathway during hypoxia/reoxygenation in neonatal rat cardiomyocytes

R Germack, JM Dickenson - Journal of molecular and cellular cardiology, 2005 - Elsevier
Three subtypes of adenosine receptors (A1, A2A and A3 ARs) are functionally expressed in
cardiomyocytes. Adenosine released during ischemia and ischemia/reperfusion plays a …

Comparative gene expression profiling of olfactory ensheathing cells from olfactory bulb and olfactory mucosa

N Guérout, C Derambure, L Drouot, N Bon‐Mardion… - Glia, 2010 - Wiley Online Library
Olfactory ensheathing cells (OEC) have the ability to promote regeneration in the nervous
system. Hence, they hold promise for cell therapy. Most of the experimental studies have …

Expression of urocortin III/stresscopin in human heart and kidney

K Takahashi, K Totsune, O Murakami… - The Journal of …, 2004 - academic.oup.com
Abstract Urocortin III (Ucn III)/stresscopin (SCP) is a novel peptide of the corticotropin-
releasing factor (CRF) family and is a specific ligand for the CRF type 2 receptor. We wished …

Atorvastatin and myocardial reperfusion injury: new pleiotropic effect implicating multiple prosurvival signaling

CA Efthymiou, MM Mocanu… - Journal of cardiovascular …, 2005 - journals.lww.com
We investigated the potential role of atorvastatin, given at reperfusion, to improve survival of
the ischemic/reperfused myocardium by activation of p44/42 MAPK and p38 MAPK with its …