The blood–brain barrier (BBB) is a highly specialized neurovascular unit, initially described
as an intact barrier to prevent toxins, pathogens, and potentially harmful substances from …

The blood–brain barrier (BBB) is a unique and selective feature of the central nervous
system's vasculature. BBB dysfunction has been observed as an early sign of Alzheimer's …

The blood-brain barrier (BBB) is a fundamental component of the central nervous system
(CNS). Its functional and structural integrity is vital to maintain the homeostasis of the brain …

Key points The blood–brain barrier (BBB) is an important and dynamic structure which
contributes to homeostasis in the central nervous system. BBB permeability changes occur …

In this study, S1PR2 was reckoned as a brand-new GPCR target for designing inhibitors to
reverse 5-FU resistance. Herein a series of pyrrolidine pyrazoles as the S1PR2 inhibitors …

Tissue-nonspecific alkaline phosphatase (TNAP) is an ectoenzyme bound to the plasma
membranes of numerous cells via a glycosylphosphatidylinositol (GPI) moiety. TNAP's …

Background: Cross-sectional studies suggest normal appearing white matter (NAWM)
integrity loss may lead to cortical atrophy in late-stage relapsing-remitting multiple sclerosis …

The blood–brain barrier (BBB) and tight junction (TJ) proteins maintain the homeostasis of
the central nervous system (CNS). The dysfunction of BBB allows peripheral T cells …

Background In relapsing-remitting multiple sclerosis (RRMS), early disease control reduces
the risk of permanent disability. The blood–brain barrier (BBB) is compromised in MS, and its …

Epilepsy is characterized by abnormal synchronous electrical activity of neurons in the brain.
The blood-brain barrier, which is mainly composed of endothelial cells, pericytes, astrocytes …