Regulated exocytosis of secretory granules or dense-core granules has been examined in
many well-characterized cell types including neurons, neuroendocrine, endocrine, exocrine …

Eosinophils are specialized white blood cells, which are involved in the pathology of diverse
allergic and nonallergic inflammatory diseases. Eosinophils are traditionally known as …

Secretory granules are specialized intracellular organelles that serve as a storage pool for
selected secretory products. The exocytosis of secretory granules is markedly amplified …

Summary von W illebrand factor (VWF) plays key roles in both primary and secondary
hemostasis by capturing platelets and chaperoning clotting factor VIII, respectively. It is …

Peptidomics and genomics analyses were used to study an anti-infection array of peptides
of amphibian skin. 372 cDNA sequences of antimicrobial peptides were characterized from …

For regulated secretion, mast cells and several other cell types utilize compound exocytosis,
a combination of granule–plasma membrane and granule–granule fusions. The molecular …

Background Mast cells are versatile key components of allergy and inflammation known to
respond to both innate and adaptive immunologic stimuli. However, the response of …

We report an approach to spatially resolve the content across nanometer neuroendocrine
vesicles in nerve-like cells by correlating super high-resolution mass spectrometry imaging …

Inflammatory cells secrete proteins from intracellular vesicles or granules by a process
referred to either as exocytosis or as degranulation, which is common to all cell types …

A novel antimicrobial peptide, anoplin, was purified from the venom of the solitary wasp
Anoplius samariensis. The sequence was mostly analyzed by mass spectrometry, which …