α-lipoic acid (ALA, thioctic acid) is an organosulfur component produced from plants,
animals, and humans. It has various properties, among them great antioxidant potential and …

Cardiovascular disease is a major complication of diabetes mellitus, and improved
strategies for prevention and treatment are needed. Endothelial dysfunction contributes to …

Background The molecular nature of lipoic acid (LA) clarifies its capability of taking part to a
variety of biochemical reactions where redox state is meaningful. The pivotal action of LA is …

The important roles of reactive oxygen species in diseases related to aging and the
necessity and benefits of antioxidative nutraceuticals in the prevention of diseases and …

Abstract α-Lipoic acid (LA; 5-(1, 2-dithiolan-3-yl) pentanoic acid) was originally isolated from
bovine liver by Reed et al. in 1951. LA was once considered a vitamin. Subsequently, it was …

Mitochondrial function and specifically its implication in cellular redox/oxidative balance is
fundamental in controlling the life and death of cells, and has been implicated in a wide …

Aging is a universal process that began with the origination of life about 3.5 billion years
ago. Accumulation of the diverse deleterious changes produced by aging throughout the …

Mitochondria play a vital role in maintaining cellular energy homeostasis, regulating
apoptosis, and controlling redox signaling. Dysfunction of mitochondria has been implicated …

Chronic systemic exposure of D‐galactose to mice, rats, and Drosophila causes the
acceleration of senescence and has been used as an aging model. However, the underlying …

AMP-activated protein kinase (AMPK) functions as a fuel sensor in the cell and is activated
when cellular energy is depleted. Here we report that α-lipoic acid (α-LA), a cofactor of …