Anti-colony-stimulating factor therapies for inflammatory and autoimmune diseases

JA Hamilton, AD Cook, PP Tak - Nature reviews Drug discovery, 2017 - nature.com
Granulocyte–macrophage colony-stimulating factor (GM-CSF), macrophage colony-
stimulating factor (M-CSF; also known as CSF1), granulocyte colony-stimulating factor (G …

Advances in the immunology and genetics of leprosy

Z Mi, H Liu, F Zhang - Frontiers in immunology, 2020 - frontiersin.org
Leprosy, a disease caused by the intracellular parasite Mycobacterium leprae or
Mycobacterium lepromatosis, has affected humans for more than 4,000 years and is a …

Innate immune responses in leprosy

RO Pinheiro, V Schmitz, BJA Silva, AA Dias… - Frontiers in …, 2018 - frontiersin.org
Leprosy is an infectious disease that may present different clinical forms depending on host
immune response to Mycobacterium leprae. Several studies have clarified the role of …

Type 1 reaction in leprosy: a model for a better understanding of tissue immunity under an immunopathological condition

PR Andrade, RO Pinheiro, AM Sales… - Expert review of …, 2015 - Taylor & Francis
Type 1 reaction (T1R) or reversal reaction is the leading cause of physical disabilities and
deformities in leprosy. Leprosy patients, even after being considered cured and released …

DNA sensing via TLR-9 constitutes a major innate immunity pathway activated during erythema nodosum leprosum

AA Dias, CO Silva, JPS Santos… - The Journal of …, 2016 - journals.aai.org
The chronic course of lepromatous leprosy may be interrupted by acute inflammatory
episodes known as erythema nodosum leprosum (ENL). Despite its being a major cause of …

Role of TEFFECTOR/MEMORY Cells, TBX21 Gene Expression and T-Cell Homing Receptor on Type 1 Reaction in Borderline Lepromatous Leprosy Patients

LN Dos Santos, PHL da Silva, IMP Alvim, JAC Nery… - PLoS …, 2016 - journals.plos.org
In spite of hyporesponsivity to Mycobacterium leprae, borderline lepromatous (BL) patients
show clinical and immunological instability, and undergo frequent acute inflammatory …

The Type I Interferon Pathway Is Upregulated in the Cutaneous Lesions and Blood of Multibacillary Leprosy Patients With Erythema Nodosum Leprosum

TLSA Rosa, MA Mendes, NRC Linhares… - Frontiers in …, 2022 - frontiersin.org
In leprosy patients, acute inflammatory episodes, known as erythema nodosum leprosum
(ENL), are responsible for high morbidity and tissue damage that occur during the course of …

The epithelioid cell in tuberculosis is secretory and not a macrophage

CL Crawford - The Journal of infectious diseases, 2015 - academic.oup.com
Jones Williams et al [3], however, have demonstrated by electron microscopy that the
epithelioid cell in tuberculosis is “primarily biosynthetic rather than phagocytic.” These …

Plasmacytoid dendritic cells in granulomatous variant of mycosis fungoides

A Fernandez‐Flores… - Journal of Cutaneous …, 2019 - Wiley Online Library
Introduction Granulomatous mycosis fungoides (MF) is a rare variant in which granulomas
are associated with other typical signs of MF. Its prognosis is worse than that of classical MF …

A skin test for latent tuberculosis

CL Crawford - SAMJ: South African Medical Journal, 2017 - scielo.org.za
To the Editor: Penn-Nicholson et al.[1] have suggested using a blood test for diagnosing
early tuberculosis. It may be possible, however, to use a skin test to diagnose latent …