Synapse dysfunction and loss are hallmarks of neurodegenerative diseases that correlate
with cognitive decline. However, the mechanisms and therapeutic strategies to prevent or …

Over a decade ago, it was discovered that microglia, the brain's immune cells, engulf
synaptic material in a process named microglial pruning. This term suggests that microglia …

Synaptic pruning is a fundamental process of neuronal circuit refinement in learning and
memory. Accumulating evidence suggests that glia participates in sculpting the neuronal …

Microglia, the resident immune cells of the central nervous system, emerge in the brain
during early embryonic development and persist throughout life. They play essential roles in …

Neurodegenerative disorders, including Alzheimer's disease, are associated with
microgliosis. Microglia have long been considered to have detrimental roles in Alzheimer's …

Activation of the innate immune system following pattern recognition receptor binding has
emerged as one of the major pathogenic mechanisms in neurodegenerative disease …

A growing body of evidence has demonstrated a link between Alzheimer disease (AD) and
epilepsy. Late-onset epilepsy and epileptiform activity can precede cognitive deterioration in …

Microglia, the resident immune cells of the brain, are increasingly implicated in the
regulation of brain health and disease. Microglia perform multiple functions in the central …

Microglia are tissue-resident macrophages and professional phagocytes of the central
nervous system (CNS). In development, microglia-mediated phagocytosis is important for …

It is becoming increasingly clear that the dominant, century-old neurocentric view of
neurodegeneration is insufficient to explain why certain neurons degenerate, in particular …