Microglia are resident myeloid cells in the central nervous system (CNS) with a unique
developmental origin, playing essential roles in developing and maintaining the CNS …

Sialic acids, commonly found as the terminal carbohydrate on the glycocalyx of mammalian
cells, are pivotal checkpoint inhibitors of the innate immune system, particularly within the …

The single nucleotide polymorphisms rs35349669 and rs10933431 within Inositol
Polyphosphate-5-Phosphatase D (INPP5D) are strongly associated with Alzheimer's …

Alzheimer's disease (AD) is one of the progressive neurodegenerative disorders and the
most common cause of dementia in the elderly worldwide causing difficulties in the daily life …

Cell surface complex carbohydrates, known as glycans, are positioned to be the first point of
contact between two cells. Indeed, interactions between glycans with glycan-binding can …

Background We have previously described genetic polymorphisms in candidate genes that
are associated with inter-individual variations in antibody responses to mumps vaccination …

Elucidating the actions of genetic polymorphisms associated with the risk of Alzheimer's
disease (AD) may provide novel insights into underlying mechanisms. Two polymorphisms …

Background: Understanding the mechanisms whereby genetic variants influence the risk of
Alzheimer's disease (AD) may provide insights into treatments that could reduce AD risk …

Alzheimer's disease (AD) is the most common form of dementia. It affects over 155 million
people worldwide and represents a huge social and economic burden. Recent genetic …

Alzheimer's disease is a complex and multifactorial condition regulated by both genetics and
lifestyle, which ultimately results in the accumulation of β-amyloid (Aβ) and tau proteins in …