High fat with high sucrose diet leads to obesity and induces myodegeneration

S Rasool, T Geetha, TL Broderick, JR Babu - Frontiers in physiology, 2018 - frontiersin.org
Skeletal muscle utilizes both free fatty acids (FFAs) and glucose that circulate in the blood
stream. When blood glucose levels acutely increase, insulin stimulates muscle glucose …

Synthetic ERRα/β/γ agonist induces an ERRα-dependent acute aerobic exercise response and enhances exercise capacity

C Billon, S Sitaula, S Banerjee, R Welch… - ACS Chemical …, 2023 - ACS Publications
Repetitive physical exercise induces physiological adaptations in skeletal muscle that
improves exercise performance and is effective for the prevention and treatment of several …

A randomized clinical trial on the effects of exercise on muscle remodelling following bariatric surgery

S Gil, JP Kirwan, IH Murai, WS Dantas… - Journal of cachexia …, 2021 - Wiley Online Library
Background Muscle atrophy and strength loss are common adverse outcomes following
bariatric surgery. This randomized, controlled trial investigated the effects of exercise …

Diet switch pre-vaccination improves immune response and metabolic status in formerly obese mice

R Honce, A Vazquez-Pagan, B Livingston… - Nature …, 2024 - nature.com
Metabolic disease is epidemiologically linked to severe complications upon influenza virus
infection, thus vaccination is a priority in this high-risk population. Yet, vaccine responses …

Gene expression associations with body mass index in the Multi-Ethnic Study of Atherosclerosis

LB Vargas, LA Lange, K Ferrier, F Aguet… - International Journal of …, 2023 - nature.com
Background/objectives Obesity, defined as excessive fat accumulation that represents a
health risk, is increasing in adults and children, reaching global epidemic proportions. Body …

Beneficial effects of metformin on muscle atrophy induced by obesity in rats

MM Hasan, SM Shalaby, J El‐Gendy… - Journal of cellular …, 2019 - Wiley Online Library
Aim A growing interest to understand the signaling pathways mediating obesity‐induced
muscle atrophy is given. Metformin (Met) was reported to possess positive effects on …

EPA and DHA elicit distinct transcriptional responses to high-fat feeding in skeletal muscle and liver

HE Kunz, S Dasari, IR Lanza - American Journal of …, 2019 - journals.physiology.org
Omega-3 polyunsaturated fatty acids (n-3 PUFAs) exert numerous beneficial biological
effects and attenuate diet-induced insulin resistance in rodent models. In the present study …

Intermittent fasting, exercise, and dietary modification induce unique transcriptomic signatures of multiple tissues governing metabolic homeostasis during weight loss …

T Liu, Y Liu, T Yan, B Zhang, L Zhou, W Zhu… - The Journal of …, 2024 - Elsevier
Obesity and its related metabolic diseases bring great challenges to public health. In-depth
understanding on the efficacy of weight-loss interventions is critical for long-term weight …

Skeletal muscle extracellular matrix remodeling with worsening glycemic control in nonhuman primates

AD Ruggiero, A Davis, C Sherrill… - American Journal …, 2021 - journals.physiology.org
Type 2 diabetes (T2D) development may be mediated by skeletal muscle (SkM) function,
which is responsible for> 80% of circulating glucose uptake. The goals of this study were to …

Short-term caloric restriction attenuates obesity-induced pro-inflammatory response in male rhesus macaques

H Wright, M Handu, A Jankeel, I Messaoudi… - Nutrients, 2020 - mdpi.com
White adipose tissue (WAT) hypertrophy is an essential hallmark of obesity and is
associated with the activation of resident immune cells. While the benefits of caloric …